C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: 3-hydroxy-3-methylglutaryl-CoA reductase
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000287936 HMGCR-001 ENSG00000113161 9606 + 5:75337168-75362104 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000287936
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000287936 1.236±0.00 1.956±0.00 3.418±0.32 1.937±0.41 1.859±0.00 0.972±0.00 4.034±0.67 6.139±0.00 4.297±2.11 0.111±0.00 16.438±1.85 5.014±1.05 6.850±2.18

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0004420 IEA hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0005515 IPI protein binding
GO:0005778 IDA peroxisomal membrane
GO:0005783 IDA endoplasmic reticulum
GO:0005789 TAS:IEA endoplasmic reticulum membrane
GO:0006695 TAS cholesterol biosynthetic process
GO:0006743 IEA ubiquinone metabolic process
GO:0007568 IEA aging
GO:0007584 IEA response to nutrient
GO:0008158 IEA hedgehog receptor activity
GO:0008284 IEA positive regulation of cell proliferation
GO:0008299 IEA isoprenoid biosynthetic process
GO:0008542 IEA visual learning
GO:0010664 IEA negative regulation of striated muscle cell apoptotic process
GO:0010666 IEA positive regulation of cardiac muscle cell apoptotic process
GO:0015936 IEA coenzyme A metabolic process
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0016616 IEA oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0032874 IEA positive regulation of stress-activated MAPK cascade
GO:0042282 IDA hydroxymethylglutaryl-CoA reductase activity
GO:0042803 IEA protein homodimerization activity
GO:0043066 IEA negative regulation of apoptotic process
GO:0043231 IEA intracellular membrane-bounded organelle
GO:0043407 IEA negative regulation of MAP kinase activity
GO:0044255 TAS cellular lipid metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0045445 IEA myoblast differentiation
GO:0045471 IEA response to ethanol
GO:0045908 IEA negative regulation of vasodilation
GO:0048643 IEA positive regulation of skeletal muscle tissue development
GO:0048661 IEA positive regulation of smooth muscle cell proliferation
GO:0050661 IEA NADP binding
GO:0050662 IEA:IDA coenzyme binding
GO:0051262 IDA protein tetramerization
GO:0055114 IEA oxidation-reduction process
GO:0061045 IEA negative regulation of wound healing
GO:0061179 IEA negative regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070374 IEA positive regulation of ERK1 and ERK2 cascade
GO:0070402 IDA NADPH binding

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000022176 Hmgcr-001 protein_coding Mus_musculus 0 3123
ENSMUST00000170287 Hmgcr-003 protein_coding Mus_musculus 0 2713
ENSMUST00000168855 Hmgcr-006 nonsense_mediated_decay Mus_musculus 0 959
ENSMUST00000163201 Hmgcr-002 retained_intron Mus_musculus 0 887
ENSMUST00000169202 Hmgcr-004 protein_coding Mus_musculus 0 630
ENSMUST00000169945 Hmgcr-005 protein_coding Mus_musculus 0 350

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