C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: 3-hydroxy-3-methylglutaryl-CoA reductase
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000343975 HMGCR-004 ENSG00000113161 9606 + 5:75337232-75361423 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000343975
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000343975 0.523±0.00 1.251±0.00 1.384±0.00 5.716±1.45 1.213±0.05 7.578±0.00 0.637±0.18 1.594±0.00 3.183±1.14 2.048±0.30 0.423±0.00 1.994±0.61 1.767±0.29 2.263±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0004420 IEA hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0005515 IPI protein binding
GO:0005778 IDA peroxisomal membrane
GO:0005783 IDA endoplasmic reticulum
GO:0005789 TAS:IEA endoplasmic reticulum membrane
GO:0006695 TAS cholesterol biosynthetic process
GO:0008158 IEA hedgehog receptor activity
GO:0008299 IEA isoprenoid biosynthetic process
GO:0015936 IEA coenzyme A metabolic process
GO:0016020 IEA membrane
GO:0016021 IEA integral component of membrane
GO:0016616 IEA oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042282 IDA hydroxymethylglutaryl-CoA reductase activity
GO:0044255 TAS cellular lipid metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0050661 IEA NADP binding
GO:0050662 IEA:IDA coenzyme binding
GO:0051262 IDA protein tetramerization
GO:0055114 IEA oxidation-reduction process
GO:0070402 IDA NADPH binding

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000022176 Hmgcr-001 protein_coding Mus_musculus 0 1681
ENSMUST00000170287 Hmgcr-003 protein_coding Mus_musculus 0 1661
ENSMUST00000168855 Hmgcr-006 nonsense_mediated_decay Mus_musculus 0 959
ENSMUST00000163201 Hmgcr-002 retained_intron Mus_musculus 0 887
ENSMUST00000169202 Hmgcr-004 protein_coding Mus_musculus 0 736
ENSMUST00000169945 Hmgcr-005 protein_coding Mus_musculus 0 350

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