C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000021670 Hmgcr 10090 - 13:96648967-96670936 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000022176 Hmgcr-001 96648967-96670936 protein_coding
  ENSMUST00000163201 Hmgcr-002 96658883-96670875 retained_intron
  ENSMUST00000168374 Hmgcr-011 96666318-96670848 retained_intron
  ENSMUST00000168855 Hmgcr-006 96650276-96666763 nonsense_mediated_decay
  ENSMUST00000169196 Hmgcr-008 96660149-96670823 protein_coding
  ENSMUST00000169202 Hmgcr-004 96652121-96656667 protein_coding
  ENSMUST00000169945 Hmgcr-005 96650443-96652803 protein_coding
  ENSMUST00000169966 Hmgcr-007 96666115-96669654 protein_coding
  ENSMUST00000170287 Hmgcr-003 96651354-96666710 protein_coding
  ENSMUST00000171537 Hmgcr-009 96666120-96670482 protein_coding
  ENSMUST00000172440 Hmgcr-010 96665705-96666587 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000022176ENSMUST00000168855ENSMUST00000169196ENSMUST00000169202ENSMUST00000170287
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000022176 4.164±1.56 11.149±4.83 7.222±1.21 29.485±8.59 3.673±0.24 14.908±1.67 1.538±0.09 13.920±3.69 25.583±12.14 9.216±0.50 0.821±0.11 14.299±6.31 17.057±10.34 18.066±5.15
ENSMUST00000168855 N/A N/A N/A N/A 4.521±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000169196 N/A 13.971±4.34 N/A N/A 3.138±0.18 7.004±0.00 N/A N/A N/A 4.037±0.48 N/A 6.557±1.08 N/A N/A
ENSMUST00000169202 N/A 9.872±0.00 N/A 52.275±0.00 N/A N/A N/A N/A N/A N/A N/A 82.849±0.00 82.708±0.00 49.339±0.00
ENSMUST00000170287 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.208±0.00 N/A 14.073±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002XB CIL_0002XB_0003 CGP 13:96542618-96670936

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004420 IDA hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0005515 IEA protein binding
GO:0005778 IEA peroxisomal membrane
GO:0005783 IEA endoplasmic reticulum
GO:0005789 IEA endoplasmic reticulum membrane
GO:0006695 IDA cholesterol biosynthetic process
GO:0006743 IEA ubiquinone metabolic process
GO:0007568 IEA aging
GO:0007584 IEA response to nutrient
GO:0008284 IEA positive regulation of cell proliferation
GO:0008299 IEA isoprenoid biosynthetic process
GO:0008542 IGI visual learning
GO:0010664 IEA negative regulation of striated muscle cell apoptotic process
GO:0010666 IEA positive regulation of cardiac muscle cell apoptotic process
GO:0015936 IEA coenzyme A metabolic process
GO:0016021 IEA integral component of membrane
GO:0032874 IEA positive regulation of stress-activated MAPK cascade
GO:0042282 IEA hydroxymethylglutaryl-CoA reductase activity
GO:0042803 IEA protein homodimerization activity
GO:0043066 IEA negative regulation of apoptotic process
GO:0043231 IEA intracellular membrane-bounded organelle
GO:0043407 IGI negative regulation of MAP kinase activity
GO:0045445 IEA myoblast differentiation
GO:0045471 IEA response to ethanol
GO:0045908 IEA negative regulation of vasodilation
GO:0048643 IEA positive regulation of skeletal muscle tissue development
GO:0048661 IEA positive regulation of smooth muscle cell proliferation
GO:0050661 IEA NADP binding
GO:0050662 IEA coenzyme binding
GO:0051262 IEA protein tetramerization
GO:0055114 IEA oxidation-reduction process
GO:0061045 IEA negative regulation of wound healing
GO:0061179 IEA negative regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070374 IEA positive regulation of ERK1 and ERK2 cascade
GO:0070402 IEA NADPH binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000052734 hmgcra 3-hydroxy-3-methylglutaryl-Coenzyme A reductase a protein_coding Danio_rerio
ENSDARG00000059301 hmgcrb 3-hydroxy-3-methylglutaryl-Coenzyme A reductase b protein_coding Danio_rerio
ENSG00000113161 HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase protein_coding Homo_sapiens

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