C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cereblon
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000113851 CRBN 9606 - 3:3148992-3179710 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000231948 CRBN-001 3150011-3179710 protein_coding
  ENST00000424814 CRBN-005 3150011-3179674 protein_coding
  ENST00000432408 CRBN-004 3150011-3179710 protein_coding
  ENST00000450014 CRBN-010 3167430-3179674 protein_coding
  ENST00000459840 CRBN-009 3150860-3154970 retained_intron
  ENST00000478353 CRBN-011 3173887-3179704 retained_intron
  ENST00000480249 CRBN-008 3156090-3174121 retained_intron
  ENST00000482844 CRBN-007 3154550-3172923 retained_intron
  ENST00000488263 CRBN-006 3150011-3156784 retained_intron
  ENST00000491834 CRBN-003 3148992-3179691 retained_intron
  ENST00000492178 CRBN-014 3172717-3175250 retained_intron
  ENST00000498442 CRBN-013 3150988-3154192 retained_intron
  ENST00000498700 CRBN-012 3172176-3179701 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000231948ENST00000432408ENST00000450014ENST00000488263ENST00000491834ENST00000492178ENST00000498700
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000231948 5.978±0.00 10.343±0.00 3.381±0.00 11.143±2.03 7.445±0.95 7.792±3.74 4.806±2.76 N/A 4.073±0.34 4.289±1.63 7.437±0.00 5.274±2.41 5.513±1.00 16.752±1.34
ENST00000432408 N/A N/A N/A N/A N/A N/A N/A 9.419±0.00 N/A 4.339±0.00 2.200±0.00 N/A N/A N/A
ENST00000450014 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 5.276±0.00 N/A N/A N/A
ENST00000488263 N/A N/A 1.358±0.00 N/A N/A N/A N/A N/A N/A 2.662±0.00 N/A N/A N/A N/A
ENST00000491834 0.663±0.00 2.084±0.00 N/A 1.737±0.00 2.812±0.00 N/A 0.822±0.00 1.353±0.00 1.806±0.00 1.142±0.00 N/A 1.091±0.00 N/A N/A
ENST00000492178 N/A N/A N/A 24.383±0.00 N/A N/A 9.692±0.00 N/A 14.912±0.00 15.900±0.00 N/A N/A 8.089±0.00 46.647±0.00
ENST00000498700 N/A N/A N/A N/A N/A N/A N/A 5.255±0.00 N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00050N CIL_00050N_0001 CGP 3:3066326-3150879
CIL_00050M CIL_00050M_0001 CGP 3:3126916-3179710

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004176 IEA ATP-dependent peptidase activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005730 IDA nucleolus
GO:0005737 IDA cytoplasm
GO:0006200 IEA ATP catabolic process
GO:0006508 IEA proteolysis
GO:0016020 IEA membrane
GO:0016567 IEA protein ubiquitination
GO:0031464 IDA Cul4A-RING E3 ubiquitin ligase complex
GO:0032463 IEA negative regulation of protein homooligomerization
GO:0034766 IEA negative regulation of ion transmembrane transport
GO:0043161 IMP proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0090073 IEA positive regulation of protein homodimerization activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000054250 crbn cereblon protein_coding Danio_rerio
ENSMUSG00000005362 Crbn cereblon protein_coding Mus_musculus

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