C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cereblon
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000005362 Crbn 10090 - 6:106778249-106800074 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000013882 Crbn-002 106780201-106800065 protein_coding
  ENSMUST00000049675 Crbn-003 106778249-106800069 protein_coding
  ENSMUST00000113239 Crbn-001 106780201-106800074 protein_coding
  ENSMUST00000147087 Crbn-004 106788748-106800061 retained_intron
  ENSMUST00000151484 Crbn-005 106783470-106799033 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000013882ENSMUST00000049675ENSMUST00000113239ENSMUST00000151484
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000013882 3.107±0.40 5.722±1.05 4.419±0.00 3.657±0.00 4.634±1.53 2.504±0.92 2.388±0.00 4.960±0.00 3.227±0.93 4.932±0.67 5.518±0.48 4.579±1.83 3.874±0.48 6.203±1.34
ENSMUST00000049675 2.736±0.97 5.029±1.22 5.697±0.19 5.493±0.64 3.615±0.84 2.367±0.71 2.996±1.04 5.010±0.52 3.896±0.98 3.937±0.65 3.809±1.14 3.882±1.65 3.674±1.13 N/A
ENSMUST00000113239 4.522±0.98 4.968±0.60 7.503±0.00 3.713±0.00 2.947±0.30 2.816±0.02 3.543±0.67 5.268±1.01 4.511±1.21 4.656±1.17 5.532±0.00 6.339±2.53 5.981±0.26 10.893±2.37
ENSMUST00000151484 N/A 9.346±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.643±0.00 N/A 32.345±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00050N CIL_00050N_0002 CGP 6:106711975-106782474
CIL_00050M CIL_00050M_0002 CGP 6:106769120-106800074

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004176 IEA ATP-dependent peptidase activity
GO:0005515 IEA protein binding
GO:0005634 ISS nucleus
GO:0005730 IEA nucleolus
GO:0005737 ISS cytoplasm
GO:0006200 IEA ATP catabolic process
GO:0016020 IEA membrane
GO:0016567 ISS protein ubiquitination
GO:0031464 ISS Cul4A-RING E3 ubiquitin ligase complex
GO:0032463 IEA negative regulation of protein homooligomerization
GO:0034766 IEA negative regulation of ion transmembrane transport
GO:0043161 ISS proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0090073 IEA positive regulation of protein homodimerization activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000054250 crbn cereblon protein_coding Danio_rerio
ENSG00000113851 CRBN cereblon protein_coding Homo_sapiens

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