C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: proprotein convertase subtilisin/kexin type 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000115257 PCSK4 9606 - 19:1481428-1490752 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000300954 PCSK4-001 1481428-1490408 protein_coding
  ENST00000441747 PCSK4-003 1481428-1490342 retained_intron
  ENST00000586002 PCSK4-011 1483498-1484127 retained_intron
  ENST00000586074 PCSK4-005 1481986-1482667 retained_intron
  ENST00000586616 PCSK4-002 1481428-1490411 retained_intron
  ENST00000587784 PCSK4-007 1487198-1490752 processed_transcript
  ENST00000588195 PCSK4-006 1482411-1490405 retained_intron
  ENST00000588671 PCSK4-010 1487218-1490377 protein_coding
  ENST00000590057 PCSK4-008 1487293-1490737 processed_transcript
  ENST00000591201 PCSK4-004 1481428-1490335 nonsense_mediated_decay
  ENST00000591303 PCSK4-012 1482439-1483844 retained_intron
  ENST00000591687 PCSK4-009 1487964-1490446 processed_transcript
  ENST00000614078 PCSK4-013 1487848-1490184 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderBrainBreastColonHeartLungOvaryTestisENST00000300954ENST00000588195ENST00000588671ENST00000591201ENST00000591303
Transcript ID Bladder Brain Breast Colon Heart Lung Ovary Testis
ENST00000300954 N/A 1.388±0.00 N/A N/A N/A 1.040±0.00 N/A 34.051±4.35
ENST00000588195 N/A N/A 0.077±0.00 N/A 0.137±0.00 N/A N/A 40.864±0.00
ENST00000588671 0.549±0.00 N/A N/A 0.568±0.00 N/A N/A 0.544±0.00 N/A
ENST00000591201 N/A N/A N/A 0.200±0.00 N/A N/A N/A N/A
ENST00000591303 N/A N/A N/A N/A N/A 0.530±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000ZH CIL_0000ZH_0001 CGP 19:1461143-1490752
CIL_00066P CIL_00066P_0001 CGP 19:1481428-1497927

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002080 IEA acrosomal membrane
GO:0004252 IBA:IEA serine-type endopeptidase activity
GO:0006508 IBA:IEA proteolysis
GO:0007339 IEA binding of sperm to zona pellucida
GO:0007340 IEA acrosome reaction
GO:0009566 IEA fertilization
GO:0016021 IEA integral component of membrane
GO:0048240 IEA sperm capacitation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000020131 Pcsk4 proprotein convertase subtilisin/kexin type 4 protein_coding Mus_musculus

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