C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: proprotein convertase subtilisin/kexin type 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000020131 Pcsk4 10090 - 10:80321283-80329498 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000020340 Pcsk4-001 80321283-80329498 protein_coding
  ENSMUST00000128653 Pcsk4-002 80321283-80329455 nonsense_mediated_decay
  ENSMUST00000130521 Pcsk4-006 80321287-80323127 retained_intron
  ENSMUST00000135071 Pcsk4-003 80322122-80329399 nonsense_mediated_decay
  ENSMUST00000137177 Pcsk4-004 80321283-80329453 retained_intron
  ENSMUST00000147132 Pcsk4-005 80321287-80323126 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000020340ENSMUST00000128653ENSMUST00000130521ENSMUST00000135071ENSMUST00000137177ENSMUST00000147132
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000020340 N/A N/A 0.414±0.10 0.202±0.02 N/A 1.521±0.43 N/A N/A 0.740±0.22 0.703±0.00 N/A 1.020±0.08 0.300±0.00 68.386±30.44
ENSMUST00000128653 N/A N/A N/A N/A 0.295±0.00 N/A 0.334±0.00 0.417±0.00 N/A N/A 0.148±0.05 0.299±0.08 N/A N/A
ENSMUST00000130521 1.534±0.43 1.886±0.51 1.074±0.54 0.698±0.00 3.407±0.64 N/A N/A 0.953±0.00 2.115±0.73 N/A 0.587±0.25 1.982±0.00 0.710±0.23 N/A
ENSMUST00000135071 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.109±0.00 0.560±0.00 1.308±1.13 29.687±0.00
ENSMUST00000137177 0.380±0.00 0.612±0.05 0.476±0.00 0.271±0.10 1.389±0.00 1.542±0.34 N/A 0.944±0.42 1.427±0.54 1.053±0.19 0.196±0.02 1.133±0.30 0.799±0.42 41.855±5.13
ENSMUST00000147132 2.327±1.03 3.174±0.40 2.525±0.19 1.034±0.29 2.576±1.46 N/A 0.772±0.18 1.056±0.32 2.109±0.33 1.236±0.39 0.833±0.17 1.815±0.59 0.549±0.02 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000ZH CIL_0000ZH_0002 CGP 10:80318254-80329498
CIL_00066P CIL_00066P_0002 CGP 10:80321283-80336441

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002080 IDA acrosomal membrane
GO:0004252 IBA serine-type endopeptidase activity
GO:0005788 TAS endoplasmic reticulum lumen
GO:0006508 IBA proteolysis
GO:0007339 IMP binding of sperm to zona pellucida
GO:0007340 IMP acrosome reaction
GO:0009566 IMP fertilization
GO:0048240 IMP sperm capacitation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000115257 PCSK4 proprotein convertase subtilisin/kexin type 4 protein_coding Homo_sapiens

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