C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: son of sevenless homolog 1 (Drosophila)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000115904 SOS1 9606 - 2:38981396-39124345 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000395038 SOS1-003 38985686-39120450 protein_coding
  ENST00000402219 SOS1-201 38981553-39120463 protein_coding
  ENST00000426016 SOS1-001 38981396-39121051 protein_coding
  ENST00000451331 SOS1-004 39056733-39124345 protein_coding
  ENST00000461545 SOS1-005 39024121-39051357 retained_intron
  ENST00000469581 SOS1-007 38986046-38987725 retained_intron
  ENST00000472480 SOS1-008 39022876-39023823 processed_transcript
  ENST00000474390 SOS1-006 38997341-39007499 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000395038ENST00000402219ENST00000426016
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000395038 1.235±0.00 N/A 2.967±0.00 2.397±1.29 3.694±1.10 2.890±0.00 2.383±0.27 1.898±0.00 4.750±0.00 4.839±0.00 0.881±0.00 3.816±0.00 0.692±0.00 2.869±0.00
ENST00000402219 2.901±0.00 1.693±0.00 N/A 1.415±0.26 4.091±1.03 2.732±0.00 1.956±1.23 1.605±0.69 1.227±0.37 2.626±0.77 3.151±1.60 3.125±1.67 2.795±1.18 2.112±1.27
ENST00000426016 N/A N/A N/A N/A N/A 2.476±0.00 0.433±0.00 N/A N/A N/A N/A 4.008±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000675 CIL_000675_0001 CGP 2:38981396-39229588

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003677 IEA DNA binding
GO:0005085 IEA guanyl-nucleotide exchange factor activity
GO:0005088 EXP Ras guanyl-nucleotide exchange factor activity
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005100 TAS Rho GTPase activator activity
GO:0005515 IPI protein binding
GO:0005622 IEA intracellular
GO:0005829 TAS cytosol
GO:0005886 TAS plasma membrane
GO:0007165 NAS signal transduction
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007264 IEA small GTPase mediated signal transduction
GO:0007265 TAS Ras protein signal transduction
GO:0007411 TAS axon guidance
GO:0007596 TAS blood coagulation
GO:0008286 TAS insulin receptor signaling pathway
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0014069 IEA postsynaptic density
GO:0017124 IEA SH3 domain binding
GO:0030168 TAS platelet activation
GO:0032320 TAS positive regulation of Ras GTPase activity
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0043025 IEA neuronal cell body
GO:0043065 TAS positive regulation of apoptotic process
GO:0045087 TAS innate immune response
GO:0045742 IEA positive regulation of epidermal growth factor receptor signaling pathway
GO:0046982 IEA protein heterodimerization activity
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0050900 TAS leukocyte migration
GO:0051056 IEA regulation of small GTPase mediated signal transduction
GO:0051057 IEA positive regulation of small GTPase mediated signal transduction
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000042468 sos1 son of sevenless homolog 1 (Drosophila) protein_coding Danio_rerio
ENSMUSG00000024241 Sos1 son of sevenless homolog 1 (Drosophila) protein_coding Mus_musculus

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