C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: Rho/Rac guanine nucleotide exchange factor (GEF) 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000116584 ARHGEF2 9606 - 1:155946851-156007070 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000313667 ARHGEF2-002 155947942-155978427 protein_coding
  ENST00000313695 ARHGEF2-003 155946851-155978160 protein_coding
  ENST00000361247 ARHGEF2-001 155946854-155978527 protein_coding
  ENST00000368315 ARHGEF2-201 155947367-155952721 protein_coding
  ENST00000423422 ARHGEF2-017 155985375-156007070 protein_coding
  ENST00000462460 ARHGEF2-004 155946855-155990073 protein_coding
  ENST00000465079 ARHGEF2-011 155968809-155979113 retained_intron
  ENST00000470541 ARHGEF2-007 155946856-155951748 protein_coding
  ENST00000470874 ARHGEF2-009 155963127-155966479 nonsense_mediated_decay
  ENST00000470975 ARHGEF2-016 155952803-155961957 retained_intron
  ENST00000471589 ARHGEF2-010 155963140-155979099 protein_coding
  ENST00000474428 ARHGEF2-015 155952732-155962623 processed_transcript
  ENST00000476273 ARHGEF2-008 155964988-155978501 processed_transcript
  ENST00000477754 ARHGEF2-014 155946855-156002564 processed_transcript
  ENST00000487755 ARHGEF2-006 155968220-155971063 retained_intron
  ENST00000495070 ARHGEF2-005 155969248-155989499 protein_coding
  ENST00000497907 ARHGEF2-012 155964988-155978169 protein_coding
  ENST00000608543 ARHGEF2-013 155961939-155962972 retained_intron
  ENST00000609126 ARHGEF2-019 155989234-155991212 processed_transcript
  ENST00000609707 ARHGEF2-018 155965324-155969729 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000313667ENST00000313695ENST00000361247ENST00000462460ENST00000465079ENST00000470541ENST00000470975ENST00000474428ENST00000477754ENST00000487755
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000313667 N/A N/A 1.818±0.00 N/A N/A 1.508±0.00 2.548±0.00 N/A 1.416±0.00 2.762±0.00 1.304±0.00 23.753±0.00 11.231±0.00 16.700±0.00
ENST00000313695 N/A N/A N/A 5.772±0.00 2.719±0.00 N/A N/A 1.812±0.00 0.384±0.00 N/A N/A 6.290±2.85 3.480±0.00 2.442±0.00
ENST00000361247 8.600±0.00 10.562±0.00 N/A N/A 4.012±0.00 2.788±1.85 2.988±0.00 N/A 0.865±0.00 25.705±0.00 N/A 11.014±5.51 11.445±1.25 4.554±0.00
ENST00000462460 N/A N/A N/A N/A 1.231±0.00 1.316±0.00 0.787±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000465079 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.559±0.00 N/A N/A N/A
ENST00000470541 12.845±0.00 12.378±0.00 1.879±0.00 14.943±0.00 5.826±2.19 6.817±0.00 N/A 4.051±0.00 1.690±0.68 16.344±12.34 1.987±0.00 12.934±2.81 8.791±0.74 6.006±0.00
ENST00000470975 N/A N/A N/A N/A 9.516±0.00 N/A N/A N/A N/A 13.003±0.00 N/A 12.430±0.00 N/A N/A
ENST00000474428 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 5.387±0.00 N/A N/A N/A
ENST00000477754 N/A N/A N/A N/A N/A N/A N/A N/A N/A 8.609±0.00 N/A N/A N/A N/A
ENST00000487755 N/A N/A N/A N/A N/A N/A N/A 0.437±0.00 N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000898 CIL_000898_0001 VISTA 1:155789635-156392759
CIL_0008P5 CIL_0008P5_0001 VISTA 1:155795688-156399252

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000132 IEA establishment of mitotic spindle orientation
GO:0000902 IMP cell morphogenesis
GO:0005089 IDA:IEA Rho guanyl-nucleotide exchange factor activity
GO:0005515 IPI protein binding
GO:0005737 IDA cytoplasm
GO:0005794 IEA Golgi apparatus
GO:0005829 TAS cytosol
GO:0005856 IDA cytoskeleton
GO:0005874 IDA microtubule
GO:0005923 IEA tight junction
GO:0005925 IDA focal adhesion
GO:0006886 NAS intracellular protein transport
GO:0007015 IMP actin filament organization
GO:0007026 IMP negative regulation of microtubule depolymerization
GO:0007067 IEA mitotic nuclear division
GO:0007264 TAS small GTPase mediated signal transduction
GO:0008017 IDA microtubule binding
GO:0008134 ISS transcription factor binding
GO:0008270 NAS zinc ion binding
GO:0017048 IDA Rho GTPase binding
GO:0030676 IDA Rac guanyl-nucleotide exchange factor activity
GO:0031410 IEA cytoplasmic vesicle
GO:0031982 IDA vesicle
GO:0032321 IDA positive regulation of Rho GTPase activity
GO:0032587 IDA ruffle membrane
GO:0032755 IDA positive regulation of interleukin-6 production
GO:0032760 IDA positive regulation of tumor necrosis factor production
GO:0032855 IDA positive regulation of Rac GTPase activity
GO:0035023 NAS:IEA regulation of Rho protein signal transduction
GO:0035556 IEA intracellular signal transduction
GO:0042127 TAS regulation of cell proliferation
GO:0043025 IEA neuronal cell body
GO:0043065 TAS positive regulation of apoptotic process
GO:0043198 IEA dendritic shaft
GO:0043234 IDA protein complex
GO:0045087 IEA innate immune response
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046872 IEA metal ion binding
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048365 IDA Rac GTPase binding
GO:0050731 IDA positive regulation of peptidyl-tyrosine phosphorylation
GO:0050768 IEA negative regulation of neurogenesis
GO:0051056 TAS regulation of small GTPase mediated signal transduction
GO:0051092 IDA positive regulation of NF-kappaB transcription factor activity
GO:0060546 ISS negative regulation of necroptotic process
GO:0071225 IDA cellular response to muramyl dipeptide
GO:0071356 ISS cellular response to tumor necrosis factor
GO:0071474 ISS cellular hyperosmotic response
GO:0097190 TAS apoptotic signaling pathway
GO:1902042 ISS negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902219 ISS negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000040380 arhgef1a Rho guanine nucleotide exchange factor (GEF) 1a protein_coding Danio_rerio
ENSDARG00000075819 arhgef2 rho/rac guanine nucleotide exchange factor (GEF) 2 protein_coding Danio_rerio
ENSMUSG00000028059 Arhgef2 rho/rac guanine nucleotide exchange factor (GEF) 2 protein_coding Mus_musculus

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