C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: Rho/Rac guanine nucleotide exchange factor (GEF) 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000361247 ARHGEF2-001 ENSG00000116584 9606 - 1:155946854-155978527 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBreastColonHeartLiverLungOvaryPlacentaTestisENST00000361247
Transcript ID Adipose Adrenal Breast Colon Heart Liver Lung Ovary Placenta Testis
ENST00000361247 8.600±0.00 10.562±0.00 4.012±0.00 2.788±1.85 2.988±0.00 0.865±0.00 25.705±0.00 11.014±5.51 11.445±1.25 4.554±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000898 CIL_000898_0001 VISTA 1:155789635-156392759
CIL_0008P5 CIL_0008P5_0001 VISTA 1:155795688-156399252

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000132 IEA establishment of mitotic spindle orientation
GO:0000902 IMP cell morphogenesis
GO:0005089 IDA:IEA Rho guanyl-nucleotide exchange factor activity
GO:0005515 IPI protein binding
GO:0005737 IDA cytoplasm
GO:0005794 IEA Golgi apparatus
GO:0005829 TAS cytosol
GO:0005856 IDA cytoskeleton
GO:0005874 IDA microtubule
GO:0005923 IEA tight junction
GO:0005925 IDA focal adhesion
GO:0006886 NAS intracellular protein transport
GO:0007015 IMP actin filament organization
GO:0007026 IMP negative regulation of microtubule depolymerization
GO:0007067 IEA mitotic nuclear division
GO:0007264 TAS small GTPase mediated signal transduction
GO:0008017 IDA microtubule binding
GO:0008134 ISS transcription factor binding
GO:0008270 NAS zinc ion binding
GO:0017048 IDA Rho GTPase binding
GO:0030676 IDA Rac guanyl-nucleotide exchange factor activity
GO:0031410 IEA cytoplasmic vesicle
GO:0031982 IDA vesicle
GO:0032321 IEA:IDA positive regulation of Rho GTPase activity
GO:0032587 IDA ruffle membrane
GO:0032755 IDA positive regulation of interleukin-6 production
GO:0032760 IDA positive regulation of tumor necrosis factor production
GO:0032855 IDA positive regulation of Rac GTPase activity
GO:0035023 NAS:IEA regulation of Rho protein signal transduction
GO:0035556 IEA intracellular signal transduction
GO:0042127 TAS regulation of cell proliferation
GO:0043025 IEA neuronal cell body
GO:0043065 TAS positive regulation of apoptotic process
GO:0043198 IEA dendritic shaft
GO:0043234 IDA protein complex
GO:0045087 IEA innate immune response
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048365 IDA Rac GTPase binding
GO:0050731 IDA positive regulation of peptidyl-tyrosine phosphorylation
GO:0050768 IEA negative regulation of neurogenesis
GO:0051056 TAS regulation of small GTPase mediated signal transduction
GO:0051092 IDA positive regulation of NF-kappaB transcription factor activity
GO:0060546 ISS negative regulation of necroptotic process
GO:0071225 IDA cellular response to muramyl dipeptide
GO:0071356 ISS cellular response to tumor necrosis factor
GO:0071474 ISS cellular hyperosmotic response
GO:0097190 TAS apoptotic signaling pathway
GO:1902042 ISS negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902219 ISS negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000029694 Arhgef2-001 protein_coding Mus_musculus 0 3037
ENSMUST00000176804 Arhgef2-008 protein_coding Mus_musculus 0 2998
ENSMUST00000175903 Arhgef2-031 protein_coding Mus_musculus 0 2964
ENSMUST00000177303 Arhgef2-030 protein_coding Mus_musculus 0 2959
ENSMUST00000176500 Arhgef2-003 protein_coding Mus_musculus 0 2959
ENSMUST00000107510 Arhgef2-005 protein_coding Mus_musculus 0 2953
ENSMUST00000177498 Arhgef2-002 protein_coding Mus_musculus 0 2926
ENSMUST00000175779 Arhgef2-004 protein_coding Mus_musculus 0 2924
ENSMUST00000170653 Arhgef2-006 protein_coding Mus_musculus 0 2920
ENSMUST00000177418 Arhgef2-007 retained_intron Mus_musculus 0 1923
ENSMUST00000175911 Arhgef2-009 protein_coding Mus_musculus 0 1892
ENSMUST00000176539 Arhgef2-013 protein_coding Mus_musculus 0 957
ENSMUST00000177091 Arhgef2-010 retained_intron Mus_musculus 0 937
ENSMUST00000176243 Arhgef2-017 protein_coding Mus_musculus 0 778
ENSMUST00000177023 Arhgef2-014 protein_coding Mus_musculus 0 743
ENSMUST00000176528 Arhgef2-027 processed_transcript Mus_musculus 0 560
ENSMUST00000176401 Arhgef2-024 retained_intron Mus_musculus 0 516
ENSMUST00000176079 Arhgef2-023 retained_intron Mus_musculus 0 459
ENSMUST00000176123 Arhgef2-025 retained_intron Mus_musculus 0 455
ENSMUST00000176316 Arhgef2-019 protein_coding Mus_musculus 0 451
ENSMUST00000176879 Arhgef2-018 protein_coding Mus_musculus 0 425
ENSMUST00000176301 Arhgef2-026 retained_intron Mus_musculus 0 403
ENSMUST00000176307 Arhgef2-016 protein_coding Mus_musculus 0 377
ENSMUST00000175745 Arhgef2-022 protein_coding Mus_musculus 0 374
ENSMUST00000177099 Arhgef2-028 retained_intron Mus_musculus 0 324
ENSMUST00000177120 Arhgef2-021 retained_intron Mus_musculus 0 309
ENSMUST00000176400 Arhgef2-020 retained_intron Mus_musculus 0 307

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