C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: rho/rac guanine nucleotide exchange factor (GEF) 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000028059 Arhgef2 10090 + 3:88607454-88648052 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000029694 Arhgef2-001 88621106-88648052 protein_coding
  ENSMUST00000107510 Arhgef2-005 88621292-88648050 protein_coding
  ENSMUST00000170653 Arhgef2-006 88621436-88648048 protein_coding
  ENSMUST00000175745 Arhgef2-022 88629571-88632334 protein_coding
  ENSMUST00000175749 Arhgef2-011 88607659-88617339 processed_transcript
  ENSMUST00000175779 Arhgef2-004 88616517-88646895 protein_coding
  ENSMUST00000175903 Arhgef2-031 88607791-88646929 protein_coding
  ENSMUST00000175911 Arhgef2-009 88622921-88640708 protein_coding
  ENSMUST00000176079 Arhgef2-023 88632196-88633590 retained_intron
  ENSMUST00000176123 Arhgef2-025 88632733-88633638 retained_intron
  ENSMUST00000176226 Arhgef2-012 88607454-88614577 processed_transcript
  ENSMUST00000176243 Arhgef2-017 88623354-88633617 protein_coding
  ENSMUST00000176272 Arhgef2-029 88643932-88646965 processed_transcript
  ENSMUST00000176301 Arhgef2-026 88634323-88635076 retained_intron
  ENSMUST00000176307 Arhgef2-016 88622459-88632926 protein_coding
  ENSMUST00000176316 Arhgef2-019 88629442-88632976 protein_coding
  ENSMUST00000176400 Arhgef2-020 88621548-88633060 retained_intron
  ENSMUST00000176401 Arhgef2-024 88621460-88634462 retained_intron
  ENSMUST00000176500 Arhgef2-003 88616143-88648052 protein_coding
  ENSMUST00000176514 Arhgef2-015 88614421-88617501 processed_transcript
  ENSMUST00000176528 Arhgef2-027 88631911-88634662 processed_transcript
  ENSMUST00000176539 Arhgef2-013 88615367-88634499 protein_coding
  ENSMUST00000176804 Arhgef2-008 88621125-88646863 protein_coding
  ENSMUST00000176879 Arhgef2-018 88629473-88632992 protein_coding
  ENSMUST00000177023 Arhgef2-014 88614609-88633595 protein_coding
  ENSMUST00000177091 Arhgef2-010 88632918-88637816 retained_intron
  ENSMUST00000177099 Arhgef2-028 88642426-88643912 retained_intron
  ENSMUST00000177120 Arhgef2-021 88629469-88632101 retained_intron
  ENSMUST00000177303 Arhgef2-030 88621555-88646929 protein_coding
  ENSMUST00000177418 Arhgef2-007 88621138-88639536 retained_intron
  ENSMUST00000177498 Arhgef2-002 88616143-88647532 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000029694ENSMUST00000107510ENSMUST00000170653ENSMUST00000175779ENSMUST00000175903ENSMUST00000176272ENSMUST00000176500ENSMUST00000176528ENSMUST00000176804ENSMUST00000177303ENSMUST00000177418ENSMUST00000177498
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000029694 9.651±2.92 2.872±1.06 7.521±0.38 17.016±2.52 6.356±1.94 4.642±0.86 4.443±1.02 8.443±0.33 2.345±1.78 17.200±0.65 1.607±0.65 7.007±2.42 9.698±4.79 N/A
ENSMUST00000107510 N/A 1.000±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.900±0.00 N/A N/A
ENSMUST00000170653 N/A N/A 2.641±0.00 13.022±6.17 N/A N/A N/A N/A 1.045±0.20 N/A 1.035±0.00 7.368±2.71 3.829±1.37 N/A
ENSMUST00000175779 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 30.629±0.83
ENSMUST00000175903 N/A N/A N/A N/A N/A 3.027±0.96 N/A N/A N/A 8.608±0.66 N/A N/A N/A 48.716±27.93
ENSMUST00000176272 N/A 9.268±3.09 N/A N/A 27.161±1.79 15.220±2.03 N/A 31.366±3.64 1.188±0.29 N/A N/A 22.213±5.78 N/A N/A
ENSMUST00000176500 N/A N/A 2.953±0.08 N/A N/A N/A N/A N/A N/A N/A 2.601±0.63 3.786±0.30 2.307±0.00 N/A
ENSMUST00000176528 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 48.525±0.00
ENSMUST00000176804 N/A N/A N/A N/A 4.783±0.96 N/A 2.154±0.00 N/A 0.305±0.14 N/A N/A 4.801±1.73 N/A N/A
ENSMUST00000177303 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.721±0.37 N/A N/A
ENSMUST00000177418 N/A N/A N/A N/A N/A N/A N/A N/A 0.306±0.08 N/A N/A N/A N/A N/A
ENSMUST00000177498 6.017±0.94 1.158±0.00 2.625±0.00 N/A 4.875±1.09 3.297±0.60 2.444±0.51 3.553±0.22 N/A 10.247±1.57 1.340±0.00 3.408±0.92 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008P5 CIL_0008P5_0002 VISTA 3:88218217-88823366
CIL_000898 CIL_000898_0002 VISTA 3:88224783-88827970

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000132 IMP establishment of mitotic spindle orientation
GO:0000902 IDA:ISS cell morphogenesis
GO:0005089 IDA:ISS Rho guanyl-nucleotide exchange factor activity
GO:0005515 IPI protein binding
GO:0005737 ISS cytoplasm
GO:0005794 IEA Golgi apparatus
GO:0005856 ISS cytoskeleton
GO:0005874 ISS microtubule
GO:0005923 IEA tight junction
GO:0005925 IEA focal adhesion
GO:0007015 IPI:ISS actin filament organization
GO:0007026 ISS negative regulation of microtubule depolymerization
GO:0007067 IEA mitotic nuclear division
GO:0008017 IDA:ISS microtubule binding
GO:0017048 ISS Rho GTPase binding
GO:0030676 ISS Rac guanyl-nucleotide exchange factor activity
GO:0031410 IEA cytoplasmic vesicle
GO:0031982 ISS vesicle
GO:0032321 IDA:ISS positive regulation of Rho GTPase activity
GO:0032587 ISS ruffle membrane
GO:0032755 ISS positive regulation of interleukin-6 production
GO:0032760 ISS positive regulation of tumor necrosis factor production
GO:0032855 ISS positive regulation of Rac GTPase activity
GO:0035023 IDA regulation of Rho protein signal transduction
GO:0035556 IEA intracellular signal transduction
GO:0043025 IDA neuronal cell body
GO:0043198 IDA dendritic shaft
GO:0043234 ISS protein complex
GO:0045087 IEA innate immune response
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0046872 IEA metal ion binding
GO:0048365 ISS Rac GTPase binding
GO:0050731 ISS positive regulation of peptidyl-tyrosine phosphorylation
GO:0050768 IMP negative regulation of neurogenesis
GO:0051092 ISS positive regulation of NF-kappaB transcription factor activity
GO:0071225 ISS cellular response to muramyl dipeptide

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000040380 arhgef1a Rho guanine nucleotide exchange factor (GEF) 1a protein_coding Danio_rerio
ENSDARG00000075819 arhgef2 rho/rac guanine nucleotide exchange factor (GEF) 2 protein_coding Danio_rerio
ENSG00000116584 ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 protein_coding Homo_sapiens

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