C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: NIMA-related kinase 6
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000119408 NEK6 9606 + 9:124257606-124353307 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000320246 NEK6-002 124257970-124353307 protein_coding
  ENST00000373596 NEK6-007 124261473-124327445 protein_coding
  ENST00000373600 NEK6-003 124257963-124353307 protein_coding
  ENST00000373603 NEK6-004 124257606-124353307 protein_coding
  ENST00000394199 NEK6-201 124292941-124352438 protein_coding
  ENST00000422297 NEK6-001 124291979-124339608 protein_coding
  ENST00000423785 NEK6-009 124286440-124326405 protein_coding
  ENST00000425237 NEK6-008 124261473-124339614 protein_coding
  ENST00000444973 NEK6-005 124258260-124339607 protein_coding
  ENST00000447379 NEK6-010 124299985-124326438 protein_coding
  ENST00000454453 NEK6-006 124258261-124347797 protein_coding
  ENST00000539416 NEK6-202 124292420-124352438 protein_coding
  ENST00000540326 NEK6-203 124257606-124352438 protein_coding
  ENST00000545174 NEK6-204 124258251-124352438 protein_coding
  ENST00000546191 NEK6-205 124291971-124352438 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000320246ENST00000373600ENST00000394199ENST00000423785ENST00000425237ENST00000444973ENST00000545174ENST00000546191
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000320246 3.361±0.00 4.670±0.00 2.196±0.00 2.655±0.37 3.440±0.00 2.364±0.00 0.710±0.32 3.919±2.77 3.953±0.41 3.779±0.48 N/A 1.013±0.00 3.801±0.70 1.519±0.00
ENST00000373600 N/A N/A N/A N/A 0.633±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000394199 N/A N/A N/A N/A 2.336±0.00 N/A 0.406±0.00 3.178±0.00 N/A N/A 1.217±0.00 2.203±0.00 10.246±0.46 N/A
ENST00000423785 N/A N/A N/A N/A N/A N/A 0.627±0.00 N/A 4.025±0.00 N/A N/A 2.594±0.00 N/A N/A
ENST00000425237 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.590±0.00
ENST00000444973 N/A N/A N/A 12.592±0.00 N/A N/A N/A N/A N/A N/A N/A 24.514±0.00 32.646±0.00 5.925±0.00
ENST00000545174 2.324±0.00 8.327±0.00 N/A 2.914±2.17 3.513±0.10 2.477±0.00 N/A 5.170±0.00 11.349±9.63 6.776±0.00 N/A 5.963±0.00 6.076±2.40 2.823±1.09
ENST00000546191 N/A N/A N/A N/A 1.231±0.00 N/A N/A N/A N/A 3.521±0.00 N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007MV CIL_0007MV_0001 UCNEbase 9:123742251-124385977
CIL_0008N3 CIL_0008N3_0001 VISTA 9:123985007-124587009
CIL_0006WH CIL_0006WH_0001 CGP 9:124001670-124353307
CIL_00098L CIL_00098L_0001 VISTA 9:124060941-124661966
CIL_0006WG CIL_0006WG_0001 CGP 9:124257606-124415444

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000278 TAS mitotic cell cycle
GO:0000287 IDA magnesium ion binding
GO:0000910 TAS cytokinesis
GO:0004672 IEA protein kinase activity
GO:0004674 IEA:IDA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0004871 IMP signal transducer activity
GO:0005515 IPI protein binding
GO:0005524 IEA:IDA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005874 IEA microtubule
GO:0006468 IEA:IDA protein phosphorylation
GO:0006915 IEA apoptotic process
GO:0007059 IDA chromosome segregation
GO:0007067 IEA mitotic nuclear division
GO:0007077 TAS mitotic nuclear envelope disassembly
GO:0007165 IMP signal transduction
GO:0007346 TAS regulation of mitotic cell cycle
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0019894 IPI kinesin binding
GO:0019901 IPI protein kinase binding
GO:0030071 IDA regulation of mitotic metaphase/anaphase transition
GO:0031572 IMP G2 DNA damage checkpoint
GO:0043123 IMP positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0046777 IDA protein autophosphorylation
GO:0051225 TAS spindle assembly
GO:2000772 TAS regulation of cellular senescence

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000037963 nek6 NIMA (never in mitosis gene a)-related kinase 6 protein_coding Danio_rerio
ENSMUSG00000026749 Nek6 NIMA (never in mitosis gene a)-related expressed kinase 6 protein_coding Mus_musculus

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