C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: DNA (cytosine-5-)-methyltransferase 3 alpha
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000119772 DNMT3A 9606 - 2:25227855-25342590 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000264709 DNMT3A-001 25227855-25342590 protein_coding
  ENST00000321117 DNMT3A-011 25232976-25341885 protein_coding
  ENST00000380746 DNMT3A-002 25232976-25252311 protein_coding
  ENST00000380756 DNMT3A-010 25232977-25342489 nonsense_mediated_decay
  ENST00000402667 DNMT3A-013 25234197-25252311 protein_coding
  ENST00000406659 DNMT3A-012 25281452-25342590 protein_coding
  ENST00000461228 DNMT3A-006 25239176-25243982 processed_transcript
  ENST00000466601 DNMT3A-007 25236974-25242015 retained_intron
  ENST00000470983 DNMT3A-003 25246757-25249703 processed_transcript
  ENST00000474807 DNMT3A-004 25245262-25247899 retained_intron
  ENST00000474887 DNMT3A-008 25235706-25244324 processed_transcript
  ENST00000482935 DNMT3A-015 25235785-25243979 processed_transcript
  ENST00000484184 DNMT3A-005 25246674-25247566 retained_intron
  ENST00000491288 DNMT3A-009 25236930-25243970 processed_transcript
  ENST00000496570 DNMT3A-017 25247050-25252083 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000264709ENST00000321117ENST00000380746ENST00000380756ENST00000402667ENST00000406659ENST00000474807
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000264709 1.026±0.00 0.818±0.00 N/A 1.955±0.00 1.318±0.00 1.312±0.00 0.355±0.00 2.282±0.00 0.350±0.00 1.030±0.00 1.005±0.00 3.875±2.52 0.972±0.08 N/A
ENST00000321117 1.998±0.00 1.918±0.00 N/A 0.534±0.00 N/A 0.708±0.21 0.855±0.40 0.941±0.39 0.667±0.34 2.161±0.00 1.323±0.45 1.490±0.62 2.909±0.33 2.881±0.00
ENST00000380746 N/A N/A 0.944±0.00 N/A 0.814±0.00 0.265±0.00 0.137±0.00 N/A 0.685±0.00 0.889±0.00 N/A 3.188±2.56 7.992±2.15 1.154±0.00
ENST00000380756 N/A N/A N/A N/A 0.679±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000402667 N/A N/A N/A N/A 0.909±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 3.241±0.00
ENST00000406659 N/A 3.846±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000474807 N/A N/A N/A N/A N/A N/A N/A 0.947±0.00 N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003JL CIL_0003JL_0002 CGP 2:25227855-25673647

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0000775 IEA chromosome, centromeric region
GO:0000791 IDA euchromatin
GO:0000792 IEA heterochromatin
GO:0001741 IEA XY body
GO:0003677 IDA DNA binding
GO:0003682 IEA chromatin binding
GO:0003886 IDA DNA (cytosine-5-)-methyltransferase activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005720 IEA nuclear heterochromatin
GO:0005737 IDA cytoplasm
GO:0006306 IDA DNA methylation
GO:0006346 IEA methylation-dependent chromatin silencing
GO:0006349 TAS regulation of gene expression by genetic imprinting
GO:0007283 IEA spermatogenesis
GO:0008168 IEA methyltransferase activity
GO:0010424 IEA DNA methylation on cytosine within a CG sequence
GO:0016363 IDA nuclear matrix
GO:0042802 IPI identical protein binding
GO:0043045 IEA DNA methylation involved in embryo development
GO:0043046 IEA DNA methylation involved in gamete generation
GO:0044027 IEA hypermethylation of CpG island
GO:0045322 IEA unmethylated CpG binding
GO:0046498 IEA S-adenosylhomocysteine metabolic process
GO:0046499 IEA S-adenosylmethioninamine metabolic process
GO:0046872 IEA metal ion binding
GO:0051718 IEA DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
GO:0071230 IEA cellular response to amino acid stimulus
GO:0090116 IEA C-5 methylation of cytosine

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000005394 dnmt3aa DNA (cytosine-5-)-methyltransferase 3 alpha a protein_coding Danio_rerio
ENSDARG00000015566 dnmt3ab DNA (cytosine-5-)-methyltransferase 3 alpha b protein_coding Danio_rerio
ENSMUSG00000020661 Dnmt3a DNA methyltransferase 3A protein_coding Mus_musculus

Loading