C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000239440 ARAP3-001 ENSG00000120318 9606 - 5:141653401-141682221 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBreastColonHeartKidneyLungOvaryPlacentaTestisENST00000239440
Transcript ID Adipose Adrenal Breast Colon Heart Kidney Lung Ovary Placenta Testis
ENST00000239440 3.334±0.00 2.065±0.00 2.267±0.00 2.703±0.00 1.642±1.46 2.224±0.00 4.025±0.00 2.380±0.83 1.758±0.62 0.499±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002P1 CIL_0002P1_0001 CGP 5:141639302-141682221
CIL_0006QH CIL_0006QH_0001 CGP 5:141653401-141879246

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001726 ISS ruffle
GO:0005100 ISS Rho GTPase activator activity
GO:0005515 IPI:IEA protein binding
GO:0005547 IDA phosphatidylinositol-3,4,5-trisphosphate binding
GO:0005622 IEA intracellular
GO:0005737 ISS cytoplasm
GO:0005829 TAS cytosol
GO:0005856 IEA cytoskeleton
GO:0005886 IEA plasma membrane
GO:0007010 TAS cytoskeleton organization
GO:0007165 IEA signal transduction
GO:0007264 TAS small GTPase mediated signal transduction
GO:0008060 ISS:IEA ARF GTPase activator activity
GO:0008270 IEA zinc ion binding
GO:0008360 ISS regulation of cell shape
GO:0016192 TAS vesicle-mediated transport
GO:0030027 ISS lamellipodium
GO:0030336 ISS negative regulation of cell migration
GO:0032312 IEA regulation of ARF GTPase activity
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0035021 IEA negative regulation of Rac protein signal transduction
GO:0035024 ISS negative regulation of Rho protein signal transduction
GO:0043325 IDA phosphatidylinositol-3,4-bisphosphate binding
GO:0043547 IEA positive regulation of GTPase activity
GO:0051056 TAS regulation of small GTPase mediated signal transduction

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000042944 Arap3-201 protein_coding Mus_musculus 0 5265

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