C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: T-box 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000121068 TBX2 9606 + 17:61399896-61409466 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000240328 TBX2-001 61399896-61409425 protein_coding
  ENST00000419047 TBX2-002 61399910-61409466 nonsense_mediated_decay
  ENST00000477081 TBX2-003 61400365-61409124 retained_intron
  ENST00000586986 TBX2-005 61408722-61409466 processed_transcript

Homo sapiens EnsemblGRCh38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000240328ENST00000419047ENST00000477081
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000240328 2.415±0.00 3.993±0.00 0.840±0.00 0.907±0.82 4.830±4.30 1.250±0.65 2.421±1.82 27.848±0.00 1.800±0.00 21.734±19.55 1.181±0.51 5.457±1.89 47.700±5.74 4.047±0.34
ENST00000419047 9.030±0.00 1.564±0.00 N/A N/A N/A 1.894±0.00 N/A 3.450±3.18 2.000±0.00 N/A N/A 1.282±0.73 15.856±8.65 9.186±0.00
ENST00000477081 N/A 0.365±0.00 0.760±0.00 0.062±0.00 0.221±0.00 0.501±0.06 0.216±0.00 1.554±1.47 0.292±0.02 19.686±0.00 N/A 1.198±0.00 N/A 1.563±0.31

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000703 CIL_000703_0001 CGP 17:60677453-61409466
CIL_0007RJ CIL_0007RJ_0001 VISTA 17:60951116-61552834
CIL_0007JV CIL_0007JV_0001 UCNEbase 17:61126460-61946035

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0003007 IEA heart morphogenesis
GO:0003148 ISS outflow tract septum morphogenesis
GO:0003151 ISS outflow tract morphogenesis
GO:0003203 ISS endocardial cushion morphogenesis
GO:0003256 ISS regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0003677 TAS DNA binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA:IEA nucleus
GO:0005667 IEA transcription factor complex
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0007521 ISS muscle cell fate determination
GO:0007569 IDA cell aging
GO:0008284 IDA positive regulation of cell proliferation
GO:0035909 ISS aorta morphogenesis
GO:0036302 ISS atrioventricular canal development
GO:0042733 ISS embryonic digit morphogenesis
GO:0043565 IDA sequence-specific DNA binding
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0048596 ISS embryonic camera-type eye morphogenesis
GO:0048738 ISS cardiac muscle tissue development
GO:0060021 IEA palate development
GO:0060045 ISS positive regulation of cardiac muscle cell proliferation
GO:0060465 ISS pharynx development
GO:0060560 IEA developmental growth involved in morphogenesis
GO:0060596 IEA mammary placode formation
GO:0090398 IDA cellular senescence
GO:1901208 ISS negative regulation of heart looping
GO:1901211 ISS negative regulation of cardiac chamber formation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000006120 tbx2b T-box 2b protein_coding Danio_rerio
ENSDARG00000018025 tbx2a T-box gene 2a protein_coding Danio_rerio
ENSMUSG00000000093 Tbx2 T-box 2 protein_coding Mus_musculus

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