C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: argonaute RISC catalytic component 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000123908 AGO2 9606 - 8:140531165-140635619 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000220592 AGO2-001 140531165-140635619 protein_coding
  ENST00000517293 AGO2-005 140572558-140635546 processed_transcript
  ENST00000518019 AGO2-004 140626485-140635546 processed_transcript
  ENST00000519347 AGO2-009 140535391-140539449 retained_intron
  ENST00000519980 AGO2-002 140531421-140635546 protein_coding
  ENST00000520412 AGO2-008 140532533-140541457 retained_intron
  ENST00000520628 AGO2-010 140532094-140532706 processed_transcript
  ENST00000521325 AGO2-007 140555408-140556238 retained_intron
  ENST00000523609 AGO2-003 140531421-140635546 nonsense_mediated_decay
  ENST00000524328 AGO2-006 140572902-140605888 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000220592ENST00000517293ENST00000519980ENST00000520412ENST00000523609
Transcript ID Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000220592 N/A 1.756±0.00 1.108±0.00 4.967±0.00 N/A 1.678±0.00 0.689±0.14 3.574±0.00 2.501±0.00 6.202±0.00 3.182±1.95 0.818±0.39 0.789±0.00
ENST00000517293 N/A 5.152±0.00 N/A 16.568±0.00 N/A 8.252±0.00 5.174±0.00 N/A N/A N/A N/A N/A N/A
ENST00000519980 N/A 0.541±0.00 1.778±0.00 1.900±0.00 4.528±0.00 N/A N/A 0.225±0.00 N/A 4.754±1.13 0.664±0.00 0.479±0.00 0.596±0.01
ENST00000520412 N/A N/A N/A N/A 3.461±0.00 N/A 1.716±0.00 1.138±0.00 N/A N/A N/A N/A N/A
ENST00000523609 2.228±0.00 0.512±0.00 1.259±0.00 1.217±0.00 0.769±0.00 1.329±0.00 0.524±0.05 0.709±0.00 6.584±0.00 8.058±0.00 2.746±2.05 1.219±0.14 1.048±0.18

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002XO CIL_0002XO_0001 CGP 8:140511298-140635619
CIL_0002XD CIL_0002XD_0001 CGP 8:140531165-141002216

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000340 IDA RNA 7-methylguanosine cap binding
GO:0000932 IDA cytoplasmic mRNA processing body
GO:0003676 IEA nucleic acid binding
GO:0003723 IEA RNA binding
GO:0003729 IEA mRNA binding
GO:0003743 NAS translation initiation factor activity
GO:0004521 EXP endoribonuclease activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IEA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005844 IDA polysome
GO:0005845 IDA mRNA cap binding complex
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006379 IEA mRNA cleavage
GO:0006412 NAS translation
GO:0006413 NAS translational initiation
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007219 TAS Notch signaling pathway
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0009791 IEA post-embryonic development
GO:0010467 TAS gene expression
GO:0010586 IEA miRNA metabolic process
GO:0010628 IEA positive regulation of gene expression
GO:0016020 IDA membrane
GO:0016442 IDA RISC complex
GO:0030529 IDA ribonucleoprotein complex
GO:0031047 ISS gene silencing by RNA
GO:0031054 IDA pre-miRNA processing
GO:0035068 IDA micro-ribonucleoprotein complex
GO:0035197 IDA siRNA binding
GO:0035198 IEA miRNA binding
GO:0035278 IDA negative regulation of translation involved in gene silencing by miRNA
GO:0035279 IDA mRNA cleavage involved in gene silencing by miRNA
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0044822 IDA poly(A) RNA binding
GO:0045087 TAS innate immune response
GO:0045947 IDA negative regulation of translational initiation
GO:0046872 IEA metal ion binding
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0060213 ISS positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0070551 IDA endoribonuclease activity, cleaving siRNA-paired mRNA
GO:0090502 IEA RNA phosphodiester bond hydrolysis, endonucleolytic
GO:1900153 ISS positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000061268 CU929240.1 Uncharacterized protein protein_coding Danio_rerio
ENSMUSG00000036698 Ago2 argonaute RISC catalytic subunit 2 protein_coding Mus_musculus

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