C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: solute carrier family 12 (potassium/chloride transporter), member 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000124067 SLC12A4 9606 - 16:67943474-67969601 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000316341 SLC12A4-001 67943474-67968694 protein_coding
  ENST00000422611 SLC12A4-201 67943474-67968694 protein_coding
  ENST00000537830 SLC12A4-005 67944593-67964065 protein_coding
  ENST00000541864 SLC12A4-004 67944482-67966878 protein_coding
  ENST00000570616 SLC12A4-020 67944738-67945405 nonsense_mediated_decay
  ENST00000570802 SLC12A4-018 67944485-67968553 retained_intron
  ENST00000571299 SLC12A4-008 67952216-67969601 protein_coding
  ENST00000572010 SLC12A4-003 67952242-67969192 processed_transcript
  ENST00000572037 SLC12A4-007 67944414-67968584 protein_coding
  ENST00000572476 SLC12A4-013 67949571-67950421 retained_intron
  ENST00000572766 SLC12A4-011 67949907-67951467 retained_intron
  ENST00000573023 SLC12A4-002 67947101-67968654 retained_intron
  ENST00000573702 SLC12A4-015 67950369-67951929 retained_intron
  ENST00000574665 SLC12A4-012 67949799-67951534 retained_intron
  ENST00000575857 SLC12A4-014 67945545-67947105 nonsense_mediated_decay
  ENST00000576377 SLC12A4-010 67950993-67968616 nonsense_mediated_decay
  ENST00000576462 SLC12A4-009 67957529-67968469 retained_intron
  ENST00000576513 SLC12A4-016 67948061-67950112 retained_intron
  ENST00000576616 SLC12A4-017 67944485-67968553 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000316341ENST00000422611ENST00000537830ENST00000541864ENST00000570802ENST00000572037ENST00000573023ENST00000576377ENST00000576462ENST00000576616
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000316341 8.661±0.00 N/A N/A 1.424±0.00 4.857±3.65 9.614±0.00 3.717±0.00 3.671±0.00 1.844±0.00 6.683±5.80 2.945±1.70 8.983±5.56 10.411±2.52 3.640±1.76
ENST00000422611 N/A 7.473±0.00 N/A N/A N/A N/A N/A N/A N/A 8.055±0.00 N/A N/A N/A N/A
ENST00000537830 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.742±0.00
ENST00000541864 N/A N/A 1.178±0.00 0.738±0.00 2.556±0.00 N/A 0.719±0.00 N/A N/A N/A N/A 2.915±2.27 4.781±0.00 2.897±0.00
ENST00000570802 N/A 5.153±0.00 N/A 1.889±0.00 6.030±0.00 N/A 2.998±0.00 3.554±0.00 N/A 0.929±0.00 N/A 0.590±0.00 N/A N/A
ENST00000572037 19.479±0.00 5.187±0.00 N/A 5.419±0.00 16.797±0.00 7.262±5.64 11.506±0.00 8.194±0.00 N/A 9.319±8.49 12.399±0.00 5.608±2.44 13.123±0.61 10.122±5.47
ENST00000573023 N/A N/A N/A N/A 1.444±0.00 N/A 0.535±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000576377 N/A N/A N/A N/A N/A N/A 2.260±0.00 N/A 5.745±0.00 N/A N/A 1.739±0.00 N/A N/A
ENST00000576462 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.446±0.00 N/A N/A N/A
ENST00000576616 N/A N/A N/A 0.429±0.00 N/A N/A 0.543±0.00 N/A 2.244±0.00 1.590±0.00 N/A 1.800±0.00 6.060±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000030 CIL_000030_0001 CGP 16:67934502-67944131
CIL_00003H CIL_00003H_0001 CGP 16:67939750-67969601
CIL_00003P CIL_00003P_0001 CGP 16:67943474-67980829

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005215 IEA transporter activity
GO:0005765 IDA lysosomal membrane
GO:0005886 TAS plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0006810 TAS:IEA transport
GO:0006811 TAS:IEA ion transport
GO:0006813 IEA potassium ion transport
GO:0006821 TAS chloride transport
GO:0006884 TAS cell volume homeostasis
GO:0015377 IEA cation:chloride symporter activity
GO:0015379 IEA potassium:chloride symporter activity
GO:0016020 IEA:TAS membrane
GO:0016021 IEA integral component of membrane
GO:0019901 IPI protein kinase binding
GO:0055085 IEA:TAS transmembrane transport
GO:1902476 IEA chloride transmembrane transport

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000014378 slc12a4 solute carrier family 12 (potassium/chloride transporters), member 4 protein_coding Danio_rerio
ENSMUSG00000017765 Slc12a4 solute carrier family 12, member 4 protein_coding Mus_musculus

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