C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: sirtuin 5
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000124523 SIRT5 9606 + 6:13574529-13615158 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000359782 SIRT5-003 13574594-13612289 protein_coding
  ENST00000379250 SIRT5-004 13574584-13612173 nonsense_mediated_decay
  ENST00000379262 SIRT5-001 13574601-13605739 protein_coding
  ENST00000397350 SIRT5-201 13574529-13615158 protein_coding
  ENST00000606117 SIRT5-002 13574643-13614558 protein_coding
  ENST00000606427 SIRT5-005 13574599-13588425 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000359782ENST00000379250ENST00000379262ENST00000606117ENST00000606427
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000359782 1.311±0.00 N/A N/A 2.751±0.00 1.581±0.26 2.641±0.00 3.632±1.44 4.822±2.58 0.933±0.00 0.767±0.07 5.382±0.00 2.792±0.80 1.790±0.63 2.418±0.00
ENST00000379250 2.188±0.00 1.045±0.00 0.835±0.00 3.782±0.19 1.534±0.41 4.061±0.00 4.525±1.26 5.254±0.00 3.579±1.98 1.785±0.00 2.079±0.00 3.907±1.49 2.578±0.35 3.875±0.54
ENST00000379262 N/A 0.815±0.00 N/A N/A N/A N/A N/A N/A 1.145±0.00 0.346±0.00 N/A 0.936±0.35 0.612±0.00 1.316±0.00
ENST00000606117 1.473±0.00 0.764±0.00 0.732±0.00 2.018±0.58 0.994±0.11 0.692±0.01 1.558±0.00 1.561±0.61 1.181±0.11 0.293±0.08 1.515±0.07 2.021±0.84 0.796±0.29 1.408±0.00
ENST00000606427 N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.052±0.00 N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008MO CIL_0008MO_0001 VISTA 6:13058507-13660102
CIL_0003IA CIL_0003IA_0001 CGP 6:13357830-13615158
CIL_0003I9 CIL_0003I9_0001 CGP 6:13574529-13632739

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005515 IEA protein binding
GO:0005634 TAS nucleus
GO:0005739 IDA mitochondrion
GO:0005758 IDA mitochondrial intermembrane space
GO:0005759 IDA mitochondrial matrix
GO:0005829 IDA cytosol
GO:0006342 TAS chromatin silencing
GO:0006476 IDA protein deacetylation
GO:0008270 IDA zinc ion binding
GO:0036047 IDA peptidyl-lysine demalonylation
GO:0036048 IDA protein desuccinylation
GO:0036049 IDA peptidyl-lysine desuccinylation
GO:0036054 IDA protein-malonyllysine demalonylase activity
GO:0036055 IDA protein-succinyllysine desuccinylase activity
GO:0070403 IDA:IEA NAD+ binding
GO:2000378 IDA negative regulation of reactive oxygen species metabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000039684 sirt5 sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae) protein_coding Danio_rerio
ENSMUSG00000054021 Sirt5 sirtuin 5 protein_coding Mus_musculus

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