C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: bone morphogenetic protein 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000125378 BMP4 9606 - 14:53949736-53958761 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000245451 BMP4-001 53949736-53956811 protein_coding
  ENST00000417573 BMP4-201 53949739-53954552 protein_coding
  ENST00000558489 BMP4-005 53955466-53956648 processed_transcript
  ENST00000558961 BMP4-007 53950622-53952147 protein_coding
  ENST00000558984 BMP4-003 53949741-53953455 protein_coding
  ENST00000559087 BMP4-002 53949736-53956811 protein_coding
  ENST00000559501 BMP4-006 53950255-53953429 protein_coding
  ENST00000559642 BMP4-004 53951892-53958761 protein_coding
  ENST00000609748 BMP4-008 53951423-53951880 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000245451ENST00000417573ENST00000558489ENST00000558961ENST00000558984ENST00000559087ENST00000559501ENST00000559642
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000245451 2.315±0.00 2.019±0.00 N/A N/A 3.203±0.00 8.829±0.00 N/A 2.414±0.00 0.609±0.00 6.745±0.00 N/A 1.672±0.57 6.014±2.69 2.307±0.00
ENST00000417573 N/A 0.731±0.00 N/A N/A 1.189±0.00 N/A N/A 1.067±0.00 N/A N/A N/A N/A N/A N/A
ENST00000558489 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.613±0.00 N/A N/A
ENST00000558961 N/A 4.231±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.218±0.00 N/A N/A
ENST00000558984 0.667±0.00 1.793±0.00 1.590±0.00 0.761±0.00 2.741±0.00 3.251±0.00 0.784±0.00 0.683±0.00 2.444±0.00 1.324±0.00 1.823±0.00 N/A N/A N/A
ENST00000559087 1.105±0.00 N/A N/A 0.179±0.00 N/A 3.732±0.00 0.948±0.00 2.200±0.00 N/A N/A 0.379±0.00 4.338±0.00 N/A 1.714±0.00
ENST00000559501 N/A N/A N/A N/A N/A N/A 1.059±0.00 N/A N/A 0.563±0.00 2.399±0.00 4.065±3.28 9.756±0.00 0.933±0.00
ENST00000559642 N/A N/A N/A N/A N/A N/A 0.376±0.00 N/A 4.350±0.00 1.149±0.00 N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008PK CIL_0008PK_0001 VISTA 14:53490522-54091438
CIL_0008PV CIL_0008PV_0001 VISTA 14:53513747-54115356
CIL_0008HY CIL_0008HY_0001 VISTA 14:53652860-54253781
CIL_0008KQ CIL_0008KQ_0001 VISTA 14:53920865-54521777
CIL_00090Z CIL_00090Z_0001 VISTA 14:53923660-54524764
CIL_0005GF CIL_0005GF_0001 CGP 14:53949736-54420218

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000186 IDA activation of MAPKK activity
GO:0001501 IEA skeletal system development
GO:0001525 IEA angiogenesis
GO:0001568 IEA blood vessel development
GO:0001649 IDA osteoblast differentiation
GO:0001656 IEA metanephros development
GO:0001657 IDA ureteric bud development
GO:0001658 IDA branching involved in ureteric bud morphogenesis
GO:0001707 IEA mesoderm formation
GO:0001759 IEA organ induction
GO:0001822 IMP kidney development
GO:0001823 IEP mesonephros development
GO:0001843 IEA neural tube closure
GO:0001934 IDA positive regulation of protein phosphorylation
GO:0001938 IDA positive regulation of endothelial cell proliferation
GO:0001944 IEA vasculature development
GO:0001958 ISS endochondral ossification
GO:0002043 IDA blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:0002062 ISS chondrocyte differentiation
GO:0002244 IDA hematopoietic progenitor cell differentiation
GO:0002320 IMP lymphoid progenitor cell differentiation
GO:0003014 IEA renal system process
GO:0003130 IMP BMP signaling pathway involved in heart induction
GO:0003139 IMP secondary heart field specification
GO:0003197 TAS endocardial cushion development
GO:0003279 TAS cardiac septum development
GO:0003323 IDA type B pancreatic cell development
GO:0003337 IDA mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0005125 IDA cytokine activity
GO:0005515 IPI protein binding
GO:0005576 ISS extracellular region
GO:0005578 IEA proteinaceous extracellular matrix
GO:0005615 ISS extracellular space
GO:0007182 IDA common-partner SMAD protein phosphorylation
GO:0007224 IEP smoothened signaling pathway
GO:0007281 IEA germ cell development
GO:0007500 IEA mesodermal cell fate determination
GO:0007507 IEA heart development
GO:0008083 IEA growth factor activity
GO:0008201 IEA heparin binding
GO:0008284 IEA positive regulation of cell proliferation
GO:0008285 IDA negative regulation of cell proliferation
GO:0009791 IDA post-embryonic development
GO:0009888 IEA tissue development
GO:0009948 IEA anterior/posterior axis specification
GO:0010159 IEA specification of organ position
GO:0010453 IDA regulation of cell fate commitment
GO:0010468 IEA regulation of gene expression
GO:0010595 IDA positive regulation of endothelial cell migration
GO:0010628 IEA positive regulation of gene expression
GO:0010629 IEA negative regulation of gene expression
GO:0010862 IDA positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010942 IDA positive regulation of cell death
GO:0021537 IDA telencephalon development
GO:0021904 IEA dorsal/ventral neural tube patterning
GO:0021978 IEA telencephalon regionalization
GO:0021983 IEA pituitary gland development
GO:0030198 TAS extracellular matrix organization
GO:0030218 IEA erythrocyte differentiation
GO:0030224 IDA monocyte differentiation
GO:0030225 IDA macrophage differentiation
GO:0030324 IEA lung development
GO:0030326 IEA embryonic limb morphogenesis
GO:0030501 IDA positive regulation of bone mineralization
GO:0030509 IMP BMP signaling pathway
GO:0030513 ISS positive regulation of BMP signaling pathway
GO:0030900 IEA forebrain development
GO:0032092 IDA positive regulation of protein binding
GO:0032331 IEA negative regulation of chondrocyte differentiation
GO:0032967 IDA positive regulation of collagen biosynthetic process
GO:0033085 IMP negative regulation of T cell differentiation in thymus
GO:0033088 IMP negative regulation of immature T cell proliferation in thymus
GO:0034504 IDA protein localization to nucleus
GO:0035116 IEA embryonic hindlimb morphogenesis
GO:0035990 ISS tendon cell differentiation
GO:0035993 ISS deltoid tuberosity development
GO:0040007 IEA growth
GO:0042056 IDA chemoattractant activity
GO:0042326 IDA negative regulation of phosphorylation
GO:0042475 IEA odontogenesis of dentin-containing tooth
GO:0042476 IGI odontogenesis
GO:0042487 IEA regulation of odontogenesis of dentin-containing tooth
GO:0042733 IEA embryonic digit morphogenesis
GO:0043010 IEA camera-type eye development
GO:0043065 IDA positive regulation of apoptotic process
GO:0043066 IDA negative regulation of apoptotic process
GO:0043401 IMP steroid hormone mediated signaling pathway
GO:0043407 IDA negative regulation of MAP kinase activity
GO:0045165 IEA cell fate commitment
GO:0045595 IEA regulation of cell differentiation
GO:0045597 IEA positive regulation of cell differentiation
GO:0045603 IEA positive regulation of endothelial cell differentiation
GO:0045606 IDA positive regulation of epidermal cell differentiation
GO:0045662 IDA negative regulation of myoblast differentiation
GO:0045666 IEA positive regulation of neuron differentiation
GO:0045669 IDA positive regulation of osteoblast differentiation
GO:0045778 IDA positive regulation of ossification
GO:0045786 IDA negative regulation of cell cycle
GO:0045839 IDA negative regulation of mitosis
GO:0045843 IDA negative regulation of striated muscle tissue development
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048286 IDA lung alveolus development
GO:0048333 IEA mesodermal cell differentiation
GO:0048392 IDA intermediate mesodermal cell differentiation
GO:0048593 IEA camera-type eye morphogenesis
GO:0048598 IEA embryonic morphogenesis
GO:0048646 IEA anatomical structure formation involved in morphogenesis
GO:0048660 IEA regulation of smooth muscle cell proliferation
GO:0048661 IDA positive regulation of smooth muscle cell proliferation
GO:0048663 IEA neuron fate commitment
GO:0048701 IEA embryonic cranial skeleton morphogenesis
GO:0048704 IEA embryonic skeletal system morphogenesis
GO:0048706 IEA embryonic skeletal system development
GO:0048745 ISS smooth muscle tissue development
GO:0048754 IDA branching morphogenesis of an epithelial tube
GO:0050679 IDA positive regulation of epithelial cell proliferation
GO:0050680 IEA negative regulation of epithelial cell proliferation
GO:0050918 IDA positive chemotaxis
GO:0051145 IEA smooth muscle cell differentiation
GO:0051150 IEA regulation of smooth muscle cell differentiation
GO:0055020 IMP positive regulation of cardiac muscle fiber development
GO:0060113 IEA inner ear receptor cell differentiation
GO:0060197 IEA cloacal septation
GO:0060235 IEA lens induction in camera-type eye
GO:0060272 IEA embryonic skeletal joint morphogenesis
GO:0060348 IEA bone development
GO:0060363 IEA cranial suture morphogenesis
GO:0060391 IDA positive regulation of SMAD protein import into nucleus
GO:0060393 IDA regulation of pathway-restricted SMAD protein phosphorylation
GO:0060395 IDA SMAD protein signal transduction
GO:0060425 IDA lung morphogenesis
GO:0060429 IEA epithelium development
GO:0060433 IDA bronchus development
GO:0060438 IDA trachea development
GO:0060440 IEA trachea formation
GO:0060441 IDA epithelial tube branching involved in lung morphogenesis
GO:0060442 IEA branching involved in prostate gland morphogenesis
GO:0060449 IEA bud elongation involved in lung branching
GO:0060502 IDA epithelial cell proliferation involved in lung morphogenesis
GO:0060503 IDA bud dilation involved in lung branching
GO:0060512 IEA prostate gland morphogenesis
GO:0060548 IDA negative regulation of cell death
GO:0060592 IEA mammary gland formation
GO:0060684 IEA epithelial-mesenchymal cell signaling
GO:0060686 IEA negative regulation of prostatic bud formation
GO:0060687 IEA regulation of branching involved in prostate gland morphogenesis
GO:0060688 IEA regulation of morphogenesis of a branching structure
GO:0061035 IEA regulation of cartilage development
GO:0061036 IDA positive regulation of cartilage development
GO:0061047 ISS positive regulation of branching involved in lung morphogenesis
GO:0061149 ISS BMP signaling pathway involved in ureter morphogenesis
GO:0061151 ISS BMP signaling pathway involved in renal system segmentation
GO:0061155 IDA pulmonary artery endothelial tube morphogenesis
GO:0070244 IMP negative regulation of thymocyte apoptotic process
GO:0070374 IEA positive regulation of ERK1 and ERK2 cascade
GO:0070700 IDA BMP receptor binding
GO:0071363 IEA cellular response to growth factor stimulus
GO:0071893 IDA BMP signaling pathway involved in nephric duct formation
GO:0072001 IEP renal system development
GO:0072015 IEA glomerular visceral epithelial cell development
GO:0072097 IDA negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway
GO:0072101 IDA specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway
GO:0072104 ISS glomerular capillary formation
GO:0072125 IDA negative regulation of glomerular mesangial cell proliferation
GO:0072138 IEA mesenchymal cell proliferation involved in ureteric bud development
GO:0072161 IEA mesenchymal cell differentiation involved in kidney development
GO:0072192 ISS ureter epithelial cell differentiation
GO:0072193 ISS ureter smooth muscle cell differentiation
GO:0072198 IEA mesenchymal cell proliferation involved in ureter development
GO:0072200 IDA negative regulation of mesenchymal cell proliferation involved in ureter development
GO:0072205 ISS metanephric collecting duct development
GO:0090184 IDA positive regulation of kidney development
GO:0090191 IDA negative regulation of branching involved in ureteric bud morphogenesis
GO:0090194 IDA negative regulation of glomerulus development
GO:2000005 IDA negative regulation of metanephric S-shaped body morphogenesis
GO:2000007 IDA negative regulation of metanephric comma-shaped body morphogenesis
GO:2000105 IDA positive regulation of DNA-dependent DNA replication
GO:2000137 IMP negative regulation of cell proliferation involved in heart morphogenesis
GO:2001012 IEA mesenchymal cell differentiation involved in renal system development

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000019995 bmp4 bone morphogenetic protein 4 protein_coding Danio_rerio
ENSMUSG00000021835 Bmp4 bone morphogenetic protein 4 protein_coding Mus_musculus

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