C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: bone morphogenetic protein 4
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000558984 BMP4-003 ENSG00000125378 9606 - 14:53949741-53953455 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleENST00000558984
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle
ENST00000558984 0.667±0.00 1.793±0.00 1.590±0.00 0.761±0.00 2.741±0.00 3.251±0.00 0.784±0.00 0.683±0.00 2.444±0.00 1.324±0.00 1.823±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008PK CIL_0008PK_0001 VISTA 14:53490522-54091438
CIL_0008PV CIL_0008PV_0001 VISTA 14:53513747-54115356
CIL_0008HY CIL_0008HY_0001 VISTA 14:53652860-54253781
CIL_0008KQ CIL_0008KQ_0001 VISTA 14:53920865-54521777
CIL_00090Z CIL_00090Z_0001 VISTA 14:53923660-54524764
CIL_0005GF CIL_0005GF_0001 CGP 14:53949736-54420218

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000186 IDA activation of MAPKK activity
GO:0001649 IDA osteoblast differentiation
GO:0001657 IDA ureteric bud development
GO:0001658 IDA branching involved in ureteric bud morphogenesis
GO:0001822 IMP kidney development
GO:0001823 IEP mesonephros development
GO:0001934 IDA positive regulation of protein phosphorylation
GO:0001938 IDA positive regulation of endothelial cell proliferation
GO:0001958 ISS endochondral ossification
GO:0002043 IDA blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:0002062 ISS chondrocyte differentiation
GO:0002244 IDA hematopoietic progenitor cell differentiation
GO:0002320 IMP lymphoid progenitor cell differentiation
GO:0003130 IMP BMP signaling pathway involved in heart induction
GO:0003139 IMP secondary heart field specification
GO:0003197 TAS endocardial cushion development
GO:0003279 TAS cardiac septum development
GO:0003323 IDA type B pancreatic cell development
GO:0003337 IDA mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0005125 IDA cytokine activity
GO:0005515 IPI protein binding
GO:0005576 ISS extracellular region
GO:0005578 IEA proteinaceous extracellular matrix
GO:0005615 ISS extracellular space
GO:0007182 IDA common-partner SMAD protein phosphorylation
GO:0007224 IEP smoothened signaling pathway
GO:0008083 IEA growth factor activity
GO:0008285 IDA negative regulation of cell proliferation
GO:0009791 IDA post-embryonic development
GO:0010453 IDA regulation of cell fate commitment
GO:0010595 IDA positive regulation of endothelial cell migration
GO:0010862 IDA positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010942 IDA positive regulation of cell death
GO:0021537 IDA telencephalon development
GO:0030198 TAS extracellular matrix organization
GO:0030224 IDA monocyte differentiation
GO:0030225 IDA macrophage differentiation
GO:0030501 IDA positive regulation of bone mineralization
GO:0030509 IMP BMP signaling pathway
GO:0030513 ISS positive regulation of BMP signaling pathway
GO:0032092 IDA positive regulation of protein binding
GO:0032967 IDA positive regulation of collagen biosynthetic process
GO:0033085 IMP negative regulation of T cell differentiation in thymus
GO:0033088 IMP negative regulation of immature T cell proliferation in thymus
GO:0034504 IDA protein localization to nucleus
GO:0035990 ISS tendon cell differentiation
GO:0035993 ISS deltoid tuberosity development
GO:0040007 IEA growth
GO:0042056 IDA chemoattractant activity
GO:0042326 IDA negative regulation of phosphorylation
GO:0042476 IGI odontogenesis
GO:0043065 IDA positive regulation of apoptotic process
GO:0043066 IDA negative regulation of apoptotic process
GO:0043401 IMP steroid hormone mediated signaling pathway
GO:0043407 IDA negative regulation of MAP kinase activity
GO:0045606 IDA positive regulation of epidermal cell differentiation
GO:0045662 IDA negative regulation of myoblast differentiation
GO:0045669 IDA positive regulation of osteoblast differentiation
GO:0045778 IDA positive regulation of ossification
GO:0045786 IDA negative regulation of cell cycle
GO:0045839 IDA negative regulation of mitosis
GO:0045843 IDA negative regulation of striated muscle tissue development
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048286 IDA lung alveolus development
GO:0048392 IDA intermediate mesodermal cell differentiation
GO:0048661 IDA positive regulation of smooth muscle cell proliferation
GO:0048745 ISS smooth muscle tissue development
GO:0048754 IDA branching morphogenesis of an epithelial tube
GO:0050679 IDA positive regulation of epithelial cell proliferation
GO:0050918 IDA positive chemotaxis
GO:0055020 IMP positive regulation of cardiac muscle fiber development
GO:0060391 IDA positive regulation of SMAD protein import into nucleus
GO:0060393 IDA regulation of pathway-restricted SMAD protein phosphorylation
GO:0060395 IDA SMAD protein signal transduction
GO:0060425 IDA lung morphogenesis
GO:0060433 IDA bronchus development
GO:0060438 IDA trachea development
GO:0060441 IDA epithelial tube branching involved in lung morphogenesis
GO:0060502 IDA epithelial cell proliferation involved in lung morphogenesis
GO:0060503 IDA bud dilation involved in lung branching
GO:0060548 IDA negative regulation of cell death
GO:0061036 IDA positive regulation of cartilage development
GO:0061047 ISS positive regulation of branching involved in lung morphogenesis
GO:0061149 ISS BMP signaling pathway involved in ureter morphogenesis
GO:0061151 ISS BMP signaling pathway involved in renal system segmentation
GO:0061155 IDA pulmonary artery endothelial tube morphogenesis
GO:0070244 IMP negative regulation of thymocyte apoptotic process
GO:0070700 IDA BMP receptor binding
GO:0071893 IDA BMP signaling pathway involved in nephric duct formation
GO:0072001 IEP renal system development
GO:0072097 IDA negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway
GO:0072101 IDA specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway
GO:0072104 ISS glomerular capillary formation
GO:0072125 IDA negative regulation of glomerular mesangial cell proliferation
GO:0072192 ISS ureter epithelial cell differentiation
GO:0072193 ISS ureter smooth muscle cell differentiation
GO:0072200 IDA negative regulation of mesenchymal cell proliferation involved in ureter development
GO:0072205 ISS metanephric collecting duct development
GO:0090184 IDA positive regulation of kidney development
GO:0090191 IDA negative regulation of branching involved in ureteric bud morphogenesis
GO:0090194 IDA negative regulation of glomerulus development
GO:2000005 IDA negative regulation of metanephric S-shaped body morphogenesis
GO:2000007 IDA negative regulation of metanephric comma-shaped body morphogenesis
GO:2000105 IDA positive regulation of DNA-dependent DNA replication
GO:2000137 IMP negative regulation of cell proliferation involved in heart morphogenesis

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000074077 Bmp4-001 protein_coding Mus_musculus 0 2098
ENSMUST00000100676 Bmp4-002 protein_coding Mus_musculus 0 1893
ENSMUST00000135408 Bmp4-003 retained_intron Mus_musculus 0 195
ENSMUST00000111826 Gm15217-001 protein_coding Mus_musculus 1e-28 132

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