C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: G protein-coupled receptor kinase 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000125388 GRK4 9606 + 4:2963608-3040747 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000345167 GRK4-005 2963821-3040747 protein_coding
  ENST00000398051 GRK4-002 2963608-3040727 protein_coding
  ENST00000398052 GRK4-001 2963728-3040747 protein_coding
  ENST00000503518 GRK4-004 2963634-2966889 protein_coding
  ENST00000504308 GRK4-008 3029323-3038578 processed_transcript
  ENST00000504933 GRK4-012 2963821-3040747 protein_coding
  ENST00000505271 GRK4-009 3022412-3040747 processed_transcript
  ENST00000507230 GRK4-011 2969169-2971192 retained_intron
  ENST00000509545 GRK4-007 3027911-3038878 processed_transcript
  ENST00000511827 GRK4-006 3027911-3040747 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000345167ENST00000398051ENST00000398052ENST00000503518ENST00000504933ENST00000505271ENST00000507230ENST00000511827
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000345167 N/A N/A N/A 0.992±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.441±0.00
ENST00000398051 N/A N/A N/A N/A 0.108±0.00 N/A N/A 0.421±0.00 0.191±0.00 0.199±0.00 N/A 0.767±0.00 0.352±0.00 N/A
ENST00000398052 N/A N/A N/A N/A 0.161±0.00 N/A N/A N/A 0.103±0.00 N/A N/A N/A N/A 42.835±29.10
ENST00000503518 1.578±0.00 1.204±0.00 0.497±0.00 1.136±0.38 0.979±0.35 0.584±0.49 0.352±0.00 1.025±0.71 0.510±0.02 0.610±0.27 0.872±0.69 1.062±0.91 1.089±0.26 4.030±0.00
ENST00000504933 N/A N/A N/A 0.454±0.00 N/A 0.109±0.04 N/A N/A N/A N/A N/A N/A 0.250±0.00 N/A
ENST00000505271 1.201±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.792±0.00 N/A
ENST00000507230 0.203±0.00 0.362±0.00 N/A 0.879±0.00 0.450±0.00 0.443±0.00 0.331±0.00 0.646±0.00 0.546±0.44 0.872±0.50 0.442±0.00 0.250±0.10 N/A 0.881±0.40
ENST00000511827 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.415±0.00 1.238±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00056M CIL_00056M_0001 CGP 4:2937933-3040747
CIL_000748 CIL_000748_0001 CGP 4:2963608-3243959

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002029 IEA desensitization of G-protein coupled receptor protein signaling pathway
GO:0002031 IEA G-protein coupled receptor internalization
GO:0004672 IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004703 IEA G-protein coupled receptor kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005524 IEA ATP binding
GO:0005829 IEA cytosol
GO:0006468 IEA protein phosphorylation
GO:0007165 IEA signal transduction
GO:0008277 TAS:IEA regulation of G-protein coupled receptor protein signaling pathway
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0030425 IEA dendrite
GO:0031623 IDA receptor internalization
GO:0038032 IEA termination of G-protein coupled receptor signaling pathway
GO:0043025 IEA neuronal cell body
GO:0050254 IEA rhodopsin kinase activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000070448 grk4 G protein-coupled receptor kinase 4 protein_coding Danio_rerio
ENSDARG00000070460 grk4 G protein-coupled receptor kinase 4 protein_coding Danio_rerio
ENSMUSG00000052783 Grk4 G protein-coupled receptor kinase 4 protein_coding Mus_musculus

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