C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: WNK lysine deficient protein kinase 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000126562 WNK4 9606 + 17:42780678-42796936 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000246914 WNK4-001 42780678-42796936 protein_coding
  ENST00000587705 WNK4-006 42785327-42788395 processed_transcript
  ENST00000587745 WNK4-007 42793715-42795742 protein_coding
  ENST00000591448 WNK4-002 42780681-42796936 nonsense_mediated_decay
  ENST00000592072 WNK4-004 42785327-42794489 retained_intron
  ENST00000592669 WNK4-005 42783609-42784453 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; BladderBreastKidneyLiverOvaryTestisENST00000246914ENST00000591448ENST00000592072
Transcript ID Bladder Breast Kidney Liver Ovary Testis
ENST00000246914 N/A 0.782±0.00 9.447±0.00 N/A 12.220±0.82 N/A
ENST00000591448 N/A N/A N/A N/A N/A 0.324±0.00
ENST00000592072 1.972±0.00 1.359±0.00 N/A 0.423±0.00 1.367±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004HC CIL_0004HC_0001 CGP 17:42773436-42796936
CIL_0005SA CIL_0005SA_0001 CGP 17:42780678-42798704

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004672 IEA protein kinase activity
GO:0004674 ISS:IEA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 ISS:IEA ATP binding
GO:0005737 IEA cytoplasm
GO:0005923 ISS tight junction
GO:0006468 ISS:IEA protein phosphorylation
GO:0006811 ISS ion transport
GO:0006821 IEA chloride transport
GO:0008104 IEA protein localization
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0019869 IDA chloride channel inhibitor activity
GO:0035556 ISS intracellular signal transduction
GO:0050794 ISS regulation of cellular process
GO:0050801 IMP ion homeostasis
GO:0070294 IMP renal sodium ion absorption
GO:0072156 IMP distal tubule morphogenesis
GO:0090188 IEA negative regulation of pancreatic juice secretion

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000016381 WNK4 WNK lysine deficient protein kinase 4 protein_coding Danio_rerio
ENSDARG00000061809 CABZ01084815.1 Uncharacterized protein protein_coding Danio_rerio
ENSDARG00000088967 WNK lysine deficient protein kinase 4 protein_coding Danio_rerio
ENSDARG00000088996 CABZ01069042.1 Uncharacterized protein protein_coding Danio_rerio
ENSMUSG00000035112 Wnk4 WNK lysine deficient protein kinase 4 protein_coding Mus_musculus

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