C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: WNK lysine deficient protein kinase 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000035112 Wnk4 10090 + 11:101260567-101277409 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000103108 Wnk4-001 101260598-101277409 protein_coding
  ENSMUST00000139487 Wnk4-002 101260567-101277409 nonsense_mediated_decay
  ENSMUST00000147741 Wnk4-004 101260655-101277274 nonsense_mediated_decay
  ENSMUST00000170056 Wnk4-003 101265308-101274129 nonsense_mediated_decay
  ENSMUST00000170372 Wnk4-005 101276646-101277406 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000103108ENSMUST00000139487ENSMUST00000147741ENSMUST00000170372
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000103108 2.070±1.43 0.108±0.05 2.325±0.92 1.153±0.05 0.182±0.04 6.083±1.46 2.022±1.16 19.870±8.60 1.823±1.29 1.803±0.39 0.068±0.00 2.158±0.84 3.489±2.09 1.061±0.40
ENSMUST00000139487 N/A 0.066±0.00 N/A N/A N/A 1.438±0.08 N/A N/A N/A N/A 0.036±0.01 N/A N/A N/A
ENSMUST00000147741 N/A 0.056±0.00 N/A N/A 0.172±0.06 N/A 0.393±0.11 5.725±0.62 0.193±0.00 N/A 0.069±0.02 2.364±0.44 1.519±0.98 0.419±0.00
ENSMUST00000170372 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.134±0.03 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004HC CIL_0004HC_0002 CGP 11:101253707-101277409
CIL_0005SA CIL_0005SA_0002 CGP 11:101260567-101279114

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004672 IEA protein kinase activity
GO:0004674 ISS protein serine/threonine kinase activity
GO:0005515 IPI protein binding
GO:0005524 ISS ATP binding
GO:0005737 IDA cytoplasm
GO:0005923 IDA tight junction
GO:0006468 ISS protein phosphorylation
GO:0006811 IDA ion transport
GO:0006821 IDA chloride transport
GO:0008104 IDA protein localization
GO:0019869 IEA chloride channel inhibitor activity
GO:0030644 TAS cellular chloride ion homeostasis
GO:0035556 ISS intracellular signal transduction
GO:0050794 IDA regulation of cellular process
GO:0050801 ISS ion homeostasis
GO:0070294 ISS renal sodium ion absorption
GO:0072156 ISS distal tubule morphogenesis
GO:0090188 IMP negative regulation of pancreatic juice secretion

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000016381 WNK4 WNK lysine deficient protein kinase 4 protein_coding Danio_rerio
ENSDARG00000061809 CABZ01084815.1 Uncharacterized protein protein_coding Danio_rerio
ENSDARG00000088967 WNK lysine deficient protein kinase 4 protein_coding Danio_rerio
ENSDARG00000088996 CABZ01069042.1 Uncharacterized protein protein_coding Danio_rerio
ENSG00000126562 WNK4 WNK lysine deficient protein kinase 4 protein_coding Homo_sapiens

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