C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: beclin 1, autophagy related
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000126581 BECN1 9606 - 17:42810134-42833350 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000361523 BECN1-002 42810134-42824263 protein_coding
  ENST00000438274 BECN1-003 42810308-42824287 protein_coding
  ENST00000543382 BECN1-004 42810414-42824287 retained_intron
  ENST00000585515 BECN1-011 42819324-42824282 retained_intron
  ENST00000586589 BECN1-019 42810860-42818652 protein_coding
  ENST00000586754 BECN1-013 42811724-42815995 processed_transcript
  ENST00000587880 BECN1-020 42810716-42813989 nonsense_mediated_decay
  ENST00000588276 BECN1-021 42810310-42814673 protein_coding
  ENST00000589492 BECN1-016 42813903-42815014 retained_intron
  ENST00000589493 BECN1-014 42815670-42818682 retained_intron
  ENST00000589636 BECN1-008 42820794-42833350 protein_coding
  ENST00000589663 BECN1-017 42810670-42818578 protein_coding
  ENST00000590099 BECN1-001 42810137-42824263 protein_coding
  ENST00000590185 BECN1-022 42810780-42812086 retained_intron
  ENST00000590764 BECN1-018 42810288-42814593 protein_coding
  ENST00000590852 BECN1-015 42814168-42815971 protein_coding
  ENST00000591085 BECN1-010 42818651-42824287 nonsense_mediated_decay
  ENST00000591307 BECN1-007 42820351-42824253 retained_intron
  ENST00000593112 BECN1-006 42820523-42824260 retained_intron
  ENST00000593205 BECN1-012 42814599-42824251 protein_coding
  ENST00000612631 BECN1-009 42823818-42833332 protein_coding
  ENST00000617806 BECN1-005 42810134-42824278 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000361523ENST00000586589ENST00000587880ENST00000590099ENST00000617806
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000361523 N/A N/A N/A N/A N/A 10.006±0.00 6.483±0.00 12.244±0.00 6.396±0.00 7.875±0.00 19.037±0.00 11.434±0.00 7.926±0.14 N/A
ENST00000586589 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 82.246±0.00 14.934±0.00 N/A
ENST00000587880 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 15.670±0.00 N/A N/A N/A
ENST00000590099 24.889±0.00 29.840±0.00 5.305±0.00 19.325±5.35 16.247±5.45 14.154±1.72 11.059±6.17 8.893±3.55 9.217±1.39 7.311±0.27 11.920±6.61 24.989±13.59 10.562±1.82 19.277±0.73
ENST00000617806 N/A N/A 1.001±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005SB CIL_0005SB_0001 CGP 17:42795147-42811587
CIL_0005S8 CIL_0005S8_0001 CGP 17:42798792-42833350
CIL_0005S9 CIL_0005S9_0001 CGP 17:42810134-42843758

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000045 IEA autophagic vacuole assembly
GO:0000910 IMP cytokinesis
GO:0001666 IEA response to hypoxia
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0005802 IEA trans-Golgi network
GO:0006914 IEA autophagy
GO:0006968 TAS cellular defense response
GO:0007040 IEA lysosome organization
GO:0008285 IEA negative regulation of cell proliferation
GO:0016020 IEA membrane
GO:0016023 IEA cytoplasmic membrane-bounded vesicle
GO:0016032 IEA viral process
GO:0016239 IEA positive regulation of macroautophagy
GO:0030425 IEA dendrite
GO:0033197 IEA response to vitamin E
GO:0042493 IEA response to drug
GO:0043066 TAS negative regulation of apoptotic process
GO:0043234 IEA protein complex
GO:0043565 IEA sequence-specific DNA binding
GO:0045335 IEA phagocytic vesicle
GO:0048666 IEA neuron development
GO:0050435 IEA beta-amyloid metabolic process
GO:0050790 IEA regulation of catalytic activity
GO:0051607 IEA defense response to virus
GO:0051707 IEA response to other organism
GO:0060548 IEA negative regulation of cell death
GO:0071275 IEA cellular response to aluminum ion
GO:0071364 IEA cellular response to epidermal growth factor stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000079128 becn1 beclin 1 (coiled-coil, myosin-like BCL2 interacting protein) protein_coding Danio_rerio
ENSMUSG00000035086 Becn1 beclin 1, autophagy related protein_coding Mus_musculus

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