C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: beclin 1, autophagy related
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000035086 Becn1 10090 - 11:101285952-101302286 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000041403 Becn1-002 101288262-101302286 nonsense_mediated_decay
  ENSMUST00000122817 Becn1-003 101288262-101302260 retained_intron
  ENSMUST00000126195 Becn1-011 101291383-101296307 nonsense_mediated_decay
  ENSMUST00000129863 Becn1-012 101290484-101301737 protein_coding
  ENSMUST00000130916 Becn1-001 101285952-101302286 protein_coding
  ENSMUST00000135805 Becn1-007 101289880-101292498 processed_transcript
  ENSMUST00000136535 Becn1-008 101288888-101294041 retained_intron
  ENSMUST00000137614 Becn1-009 101301461-101302241 retained_intron
  ENSMUST00000139669 Becn1-006 101298077-101302255 processed_transcript
  ENSMUST00000139997 Becn1-004 101288262-101302252 retained_intron
  ENSMUST00000140286 Becn1-010 101291530-101295436 retained_intron
  ENSMUST00000140706 Becn1-005 101295547-101302206 protein_coding
  ENSMUST00000164036 Becn1-016 101296226-101302240 retained_intron
  ENSMUST00000167667 Becn1-014 101288876-101302237 nonsense_mediated_decay
  ENSMUST00000167818 Becn1-017 101291499-101302238 nonsense_mediated_decay
  ENSMUST00000170502 Becn1-013 101295907-101302249 protein_coding
  ENSMUST00000172233 Becn1-015 101288418-101302251 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000041403ENSMUST00000122817ENSMUST00000130916ENSMUST00000139669ENSMUST00000139997ENSMUST00000140286ENSMUST00000170502
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000041403 15.297±2.87 N/A 14.408±3.50 17.979±1.38 13.071±0.82 N/A 9.164±0.34 16.353±2.63 11.182±4.51 12.450±0.00 5.996±0.96 16.528±1.85 13.682±1.64 14.702±2.37
ENSMUST00000122817 11.438±2.79 N/A 12.246±3.92 12.740±1.46 N/A 12.139±0.00 N/A N/A 12.680±2.75 9.833±1.37 4.764±0.00 12.694±2.61 6.775±0.68 N/A
ENSMUST00000130916 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.636±0.00 17.432±6.94
ENSMUST00000139669 N/A 33.351±6.94 N/A N/A N/A N/A N/A N/A N/A N/A N/A 42.200±11.09 N/A N/A
ENSMUST00000139997 N/A N/A N/A 4.954±0.00 N/A N/A N/A N/A 7.127±1.76 N/A N/A 4.978±0.53 3.822±1.34 N/A
ENSMUST00000140286 N/A N/A N/A 118.424±0.00 N/A N/A N/A N/A N/A N/A N/A 99.402±0.00 42.074±3.30 289.707±0.00
ENSMUST00000170502 N/A N/A N/A N/A 33.276±1.57 N/A N/A N/A N/A N/A N/A 55.190±12.76 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005SB CIL_0005SB_0002 CGP 11:101277968-101296317
CIL_0005S8 CIL_0005S8_0002 CGP 11:101279012-101302286
CIL_0005S9 CIL_0005S9_0002 CGP 11:101285952-101323537

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000045 IEA autophagic vacuole assembly
GO:0000910 ISS cytokinesis
GO:0001666 IEA response to hypoxia
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0005737 IDA cytoplasm
GO:0005802 IDA trans-Golgi network
GO:0005856 ISS cytoskeleton
GO:0006914 IDA autophagy
GO:0007040 IMP lysosome organization
GO:0008285 IDA negative regulation of cell proliferation
GO:0016020 ISS membrane
GO:0016023 IDA cytoplasmic membrane-bounded vesicle
GO:0016239 IGI positive regulation of macroautophagy
GO:0030425 IEA dendrite
GO:0033197 IEA response to vitamin E
GO:0042493 IEA response to drug
GO:0043234 IDA protein complex
GO:0045335 IDA phagocytic vesicle
GO:0048666 IMP neuron development
GO:0050435 IMP beta-amyloid metabolic process
GO:0050790 IMP regulation of catalytic activity
GO:0051607 IEA defense response to virus
GO:0051707 IDA response to other organism
GO:0060548 IEA negative regulation of cell death
GO:0071275 IEA cellular response to aluminum ion
GO:0071364 IEA cellular response to epidermal growth factor stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000079128 becn1 beclin 1 (coiled-coil, myosin-like BCL2 interacting protein) protein_coding Danio_rerio
ENSG00000126581 BECN1 beclin 1, autophagy related protein_coding Homo_sapiens

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