C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: kinase insert domain receptor (a type III receptor tyrosine kinase)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000128052 KDR 9606 - 4:55078477-55125589 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000263923 KDR-001 55078477-55125589 protein_coding
  ENST00000509309 KDR-003 55094850-55096720 retained_intron
  ENST00000512566 KDR-002 55104593-55125293 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000263923ENST00000512566
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000263923 11.323±0.00 9.934±0.00 2.753±0.00 1.054±0.89 6.022±3.27 5.527±3.52 5.579±3.20 8.228±1.58 4.929±0.99 11.062±2.76 1.141±0.77 2.975±0.89 38.066±5.52 3.172±2.35
ENST00000512566 N/A N/A 2.805±0.00 N/A 3.589±0.00 N/A 1.140±0.00 2.709±0.00 1.709±0.00 4.595±0.00 N/A 1.317±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001CK CIL_0001CK_0001 CGP 4:54657918-55125589
CIL_00025J CIL_00025J_0001 CGP 4:55078477-55373096

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001525 TAS angiogenesis
GO:0001541 IEA ovarian follicle development
GO:0001570 ISS vasculogenesis
GO:0001934 IDA positive regulation of protein phosphorylation
GO:0001938 IMP positive regulation of endothelial cell proliferation
GO:0001945 IEA lymph vessel development
GO:0002042 ISS cell migration involved in sprouting angiogenesis
GO:0002053 IEA positive regulation of mesenchymal cell proliferation
GO:0003158 ISS endothelium development
GO:0004672 IEA protein kinase activity
GO:0004713 IDA:IEA protein tyrosine kinase activity
GO:0004714 TAS transmembrane receptor protein tyrosine kinase activity
GO:0004716 TAS receptor signaling protein tyrosine kinase activity
GO:0005021 IDA vascular endothelial growth factor-activated receptor activity
GO:0005178 IPI integrin binding
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005576 IEA extracellular region
GO:0005634 IEA nucleus
GO:0005768 IDA endosome
GO:0005769 ISS early endosome
GO:0005794 IDA Golgi apparatus
GO:0005886 ISS plasma membrane
GO:0005887 IDA integral component of plasma membrane
GO:0006468 IEA protein phosphorylation
GO:0007169 TAS transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008284 IMP positive regulation of cell proliferation
GO:0008360 IDA regulation of cell shape
GO:0009897 IEA external side of plasma membrane
GO:0010595 IMP positive regulation of endothelial cell migration
GO:0014068 IDA positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016032 IEA viral process
GO:0016477 IEA cell migration
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IDA peptidyl-tyrosine phosphorylation
GO:0019838 IPI growth factor binding
GO:0023014 TAS signal transduction by phosphorylation
GO:0030054 ISS cell junction
GO:0030097 IEA hemopoiesis
GO:0030198 TAS extracellular matrix organization
GO:0030324 IEA lung development
GO:0030335 IMP positive regulation of cell migration
GO:0031410 IEA cytoplasmic vesicle
GO:0035162 ISS embryonic hemopoiesis
GO:0035584 IMP calcium-mediated signaling using intracellular calcium source
GO:0035924 IDA cellular response to vascular endothelial growth factor stimulus
GO:0038083 ISS peptidyl-tyrosine autophosphorylation
GO:0038084 IEA vascular endothelial growth factor signaling pathway
GO:0038085 IPI vascular endothelial growth factor binding
GO:0043066 IMP negative regulation of apoptotic process
GO:0043129 IEA surfactant homeostasis
GO:0043410 IDA positive regulation of MAPK cascade
GO:0045121 IDA membrane raft
GO:0045165 IEA cell fate commitment
GO:0045446 IEA endothelial cell differentiation
GO:0045766 IMP positive regulation of angiogenesis
GO:0046777 IDA protein autophosphorylation
GO:0048010 IDA vascular endothelial growth factor receptor signaling pathway
GO:0048286 IEA lung alveolus development
GO:0048469 IEA cell maturation
GO:0048754 IEA branching morphogenesis of an epithelial tube
GO:0050679 IEA positive regulation of epithelial cell proliferation
GO:0050927 IDA positive regulation of positive chemotaxis
GO:0051770 IDA positive regulation of nitric-oxide synthase biosynthetic process
GO:0051879 TAS Hsp90 protein binding
GO:0051894 IDA positive regulation of focal adhesion assembly
GO:0055074 IEA calcium ion homeostasis
GO:0070374 IMP positive regulation of ERK1 and ERK2 cascade
GO:0071944 IEA cell periphery
GO:0097443 ISS sorting endosome
GO:2000352 IDA negative regulation of endothelial cell apoptotic process
GO:2001214 ISS positive regulation of vasculogenesis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000017321 kdr kinase insert domain receptor (a type III receptor tyrosine kinase) protein_coding Danio_rerio
ENSMUSG00000062960 Kdr kinase insert domain protein receptor protein_coding Mus_musculus

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