C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: kinase insert domain protein receptor
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000062960 Kdr 10090 - 5:75932827-75978458 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000113516 Kdr-001 75932827-75978458 protein_coding
  ENSMUST00000149573 Kdr-002 75961244-75978458 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000113516ENSMUST00000149573
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000113516 23.996±2.94 16.341±3.39 5.671±0.11 6.131±2.65 15.108±2.49 3.452±0.74 22.662±2.22 17.049±0.42 4.143±0.89 63.705±3.77 6.266±1.82 11.081±1.70 9.610±3.55 0.618±0.16
ENSMUST00000149573 N/A 4.974±0.78 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001CK CIL_0001CK_0002 CGP 5:75574916-75978458
CIL_00025J CIL_00025J_0002 CGP 5:75932827-76155504

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001541 IMP ovarian follicle development
GO:0001570 IMP vasculogenesis
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0001938 IEA positive regulation of endothelial cell proliferation
GO:0001945 IGI lymph vessel development
GO:0002053 IMP positive regulation of mesenchymal cell proliferation
GO:0005021 IDA vascular endothelial growth factor-activated receptor activity
GO:0005178 IEA integrin binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005768 IEA endosome
GO:0005794 IEA Golgi apparatus
GO:0005887 IEA integral component of plasma membrane
GO:0008284 IEA positive regulation of cell proliferation
GO:0008360 IEA regulation of cell shape
GO:0009897 IDA external side of plasma membrane
GO:0010595 IEA positive regulation of endothelial cell migration
GO:0014068 IEA positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016477 IGI cell migration
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0019838 IPI growth factor binding
GO:0030097 IMP hemopoiesis
GO:0030324 IMP lung development
GO:0030335 IEA positive regulation of cell migration
GO:0035584 IEA calcium-mediated signaling using intracellular calcium source
GO:0035924 IEA cellular response to vascular endothelial growth factor stimulus
GO:0038084 IEA vascular endothelial growth factor signaling pathway
GO:0038085 IEA vascular endothelial growth factor binding
GO:0043066 IEA negative regulation of apoptotic process
GO:0043129 IMP surfactant homeostasis
GO:0043410 IEA positive regulation of MAPK cascade
GO:0045121 IEA membrane raft
GO:0045165 IMP cell fate commitment
GO:0045446 IDA endothelial cell differentiation
GO:0045766 IEA positive regulation of angiogenesis
GO:0046777 IEA protein autophosphorylation
GO:0048010 IDA vascular endothelial growth factor receptor signaling pathway
GO:0048286 IMP lung alveolus development
GO:0048469 IMP cell maturation
GO:0048754 IMP branching morphogenesis of an epithelial tube
GO:0050679 IMP positive regulation of epithelial cell proliferation
GO:0050927 IEA positive regulation of positive chemotaxis
GO:0051770 IEA positive regulation of nitric-oxide synthase biosynthetic process
GO:0051894 IEA positive regulation of focal adhesion assembly
GO:0055074 IDA calcium ion homeostasis
GO:0070374 IEA positive regulation of ERK1 and ERK2 cascade
GO:0071944 IDA cell periphery
GO:2000352 IEA negative regulation of endothelial cell apoptotic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000017321 kdr kinase insert domain receptor (a type III receptor tyrosine kinase) protein_coding Danio_rerio
ENSG00000128052 KDR kinase insert domain receptor (a type III receptor tyrosine kinase) protein_coding Homo_sapiens

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