C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: activating transcription factor 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000128272 ATF4 9606 + 22:39519695-39522685 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000337304 ATF4-002 39520564-39522683 protein_coding
  ENST00000396680 ATF4-201 39520564-39522685 protein_coding
  ENST00000404241 ATF4-001 39519695-39522683 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000337304ENST00000396680
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000337304 N/A 20.685±0.00 0.886±0.00 N/A 5.602±3.05 2.414±0.00 N/A N/A N/A N/A N/A 11.556±0.00 N/A 7.423±0.00
ENST00000396680 86.491±0.00 102.664±0.00 9.744±0.00 52.323±13.91 58.944±31.42 154.410±133.26 34.351±28.20 57.562±20.07 50.131±11.99 87.337±66.08 117.287±41.67 87.791±51.53 125.996±42.01 68.293±30.38

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003MS CIL_0003MS_0001 CGP 22:39499432-39522685
CIL_0005W7 CIL_0005W7_0001 CGP 22:39519695-39532855

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 IC sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001046 ISS core promoter sequence-specific DNA binding
GO:0001077 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 ISS DNA binding
GO:0003700 ISS:IEA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 ISS nucleus
GO:0005654 TAS nucleoplasm
GO:0005667 IEA transcription factor complex
GO:0005737 ISS cytoplasm
GO:0005856 IEA cytoskeleton
GO:0006094 ISS gluconeogenesis
GO:0006355 ISS:IEA regulation of transcription, DNA-templated
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0006366 ISS transcription from RNA polymerase II promoter
GO:0006520 TAS cellular amino acid metabolic process
GO:0006987 TAS activation of signaling protein activity involved in unfolded protein response
GO:0007214 IEA gamma-aminobutyric acid signaling pathway
GO:0007623 IEA circadian rhythm
GO:0008022 IEA protein C-terminus binding
GO:0030968 TAS endoplasmic reticulum unfolded protein response
GO:0032590 IEA dendrite membrane
GO:0032922 ISS circadian regulation of gene expression
GO:0034399 IDA nuclear periphery
GO:0034976 IDA response to endoplasmic reticulum stress
GO:0036091 IMP positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0043005 IDA neuron projection
GO:0043065 TAS positive regulation of apoptotic process
GO:0043267 IEA negative regulation of potassium ion transport
GO:0043525 ISS positive regulation of neuron apoptotic process
GO:0043565 IEA sequence-specific DNA binding
GO:0044212 IDA transcription regulatory region DNA binding
GO:0044267 TAS cellular protein metabolic process
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0070059 ISS intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:1903204 IGI negative regulation of oxidative stress-induced neuron death
GO:1990037 IDA Lewy body core
GO:1990440 IMP positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000038141 atf4b2 activating transcription factor 4b2 protein_coding Danio_rerio
ENSDARG00000039515 atf4b1 activating transcription factor 4b1 (tax-responsive enhancer element B67) protein_coding Danio_rerio
ENSMUSG00000042406 Atf4 activating transcription factor 4 protein_coding Mus_musculus

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