C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: activating transcription factor 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000042406 Atf4 10090 + 15:80255184-80257540 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000109605 Atf4-201 80255184-80257540 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000109605
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000109605 79.694±1.15 105.314±29.77 133.505±45.57 94.348±34.20 93.196±6.19 84.040±8.50 34.973±2.89 55.921±9.50 130.122±79.87 83.060±4.42 86.328±14.00 104.648±27.16 118.440±16.56 21.705±4.04

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003MS CIL_0003MS_0002 CGP 15:80234080-80257540
CIL_0005W7 CIL_0005W7_0002 CGP 15:80255184-80264306

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000978 IMP RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001046 IDA core promoter sequence-specific DNA binding
GO:0001077 IMP RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 IDA DNA binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005667 IDA transcription factor complex
GO:0005737 IDA cytoplasm
GO:0005856 IEA cytoskeleton
GO:0006094 IDA gluconeogenesis
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006357 IDA regulation of transcription from RNA polymerase II promoter
GO:0007214 IEA gamma-aminobutyric acid signaling pathway
GO:0007623 IEP circadian rhythm
GO:0008022 IEA protein C-terminus binding
GO:0032590 IEA dendrite membrane
GO:0032922 IMP circadian regulation of gene expression
GO:0034399 IEA nuclear periphery
GO:0034976 IDA response to endoplasmic reticulum stress
GO:0036091 IEA positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0043005 IEA neuron projection
GO:0043267 IEA negative regulation of potassium ion transport
GO:0043525 IMP positive regulation of neuron apoptotic process
GO:0044212 IEA transcription regulatory region DNA binding
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0070059 IMP intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:1903204 IEA negative regulation of oxidative stress-induced neuron death
GO:1990037 IEA Lewy body core
GO:1990440 IMP positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000038141 atf4b2 activating transcription factor 4b2 protein_coding Danio_rerio
ENSDARG00000039515 atf4b1 activating transcription factor 4b1 (tax-responsive enhancer element B67) protein_coding Danio_rerio
ENSG00000128272 ATF4 activating transcription factor 4 protein_coding Homo_sapiens

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