C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: interferon regulatory factor 5
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000128604 IRF5 9606 + 7:128937612-128950035 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000249375 IRF5-201 128938217-128950030 protein_coding
  ENST00000357234 IRF5-002 128937940-128948832 protein_coding
  ENST00000402030 IRF5-001 128937989-128950035 protein_coding
  ENST00000461416 IRF5-006 128937981-128947745 retained_intron
  ENST00000464557 IRF5-010 128937972-128945967 protein_coding
  ENST00000465603 IRF5-007 128940838-128949388 nonsense_mediated_decay
  ENST00000467002 IRF5-011 128940206-128942259 protein_coding
  ENST00000473745 IRF5-009 128940672-128949388 protein_coding
  ENST00000473787 IRF5-012 128937991-128946556 nonsense_mediated_decay
  ENST00000477535 IRF5-005 128937940-128948832 protein_coding
  ENST00000479582 IRF5-008 128937962-128946540 protein_coding
  ENST00000488569 IRF5-004 128937937-128946942 retained_intron
  ENST00000489702 IRF5-003 128937612-128946570 protein_coding
  ENST00000613821 IRF5-202 128937940-128947256 protein_coding
  ENST00000619830 IRF5-203 128940838-128948982 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000249375ENST00000357234ENST00000402030ENST00000461416ENST00000465603ENST00000473745ENST00000473787ENST00000477535ENST00000488569ENST00000613821ENST00000619830
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000249375 N/A N/A N/A 0.096±0.00 N/A 0.304±0.00 N/A N/A 0.069±0.00 N/A N/A 1.004±0.00 1.629±0.00 0.254±0.03
ENST00000357234 N/A N/A 0.613±0.00 N/A N/A N/A 0.160±0.00 N/A 0.577±0.00 1.078±0.00 N/A N/A N/A N/A
ENST00000402030 0.493±0.00 N/A N/A N/A 0.431±0.00 N/A 0.227±0.00 N/A N/A N/A N/A 1.077±0.00 N/A N/A
ENST00000461416 N/A N/A N/A 0.109±0.00 0.861±0.00 0.205±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000465603 N/A 4.683±0.00 N/A 0.423±0.14 1.292±0.00 N/A N/A 9.090±0.00 0.384±0.00 3.055±0.00 N/A 0.696±0.55 0.800±0.14 1.710±0.00
ENST00000473745 0.483±0.00 1.830±0.00 N/A N/A N/A 0.097±0.00 0.816±0.00 N/A N/A N/A N/A 0.924±0.00 1.796±0.58 N/A
ENST00000473787 N/A N/A 1.348±0.00 N/A N/A N/A N/A N/A N/A N/A 0.206±0.00 N/A N/A N/A
ENST00000477535 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.637±0.00 N/A N/A N/A N/A
ENST00000488569 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.239±0.00
ENST00000613821 N/A N/A N/A N/A N/A N/A 0.472±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000619830 N/A N/A N/A 0.214±0.00 N/A 0.238±0.00 0.049±0.00 N/A N/A N/A N/A 0.834±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001YB CIL_0001YB_0001 CGP 7:128937612-129055144

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000975 IEA regulatory region DNA binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0019221 TAS cytokine-mediated signaling pathway
GO:0032494 IDA response to peptidoglycan
GO:0032495 IDA response to muramyl dipeptide
GO:0032727 IC positive regulation of interferon-alpha production
GO:0032728 IC positive regulation of interferon-beta production
GO:0032735 IC positive regulation of interleukin-12 production
GO:0043065 IMP positive regulation of apoptotic process
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0051607 IEA defense response to virus
GO:0060333 TAS interferon-gamma-mediated signaling pathway
GO:0060337 TAS type I interferon signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000045681 irf5 interferon regulatory factor 5 protein_coding Danio_rerio
ENSMUSG00000029771 Irf5 interferon regulatory factor 5 protein_coding Mus_musculus

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