C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: eukaryotic translation initiation factor 2 alpha kinase 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000128829 EIF2AK4 9606 + 15:39934146-40035591 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000263791 EIF2AK4-001 39934153-40035590 protein_coding
  ENST00000558557 EIF2AK4-005 40002391-40035591 retained_intron
  ENST00000558629 EIF2AK4-004 39991166-40035591 retained_intron
  ENST00000558743 EIF2AK4-007 40020526-40022597 retained_intron
  ENST00000558823 EIF2AK4-009 40030393-40035481 protein_coding
  ENST00000559032 EIF2AK4-008 40021543-40026002 retained_intron
  ENST00000559311 EIF2AK4-006 40002391-40008193 processed_transcript
  ENST00000559624 EIF2AK4-002 39934146-39975429 protein_coding
  ENST00000560648 EIF2AK4-010 39934176-39946895 protein_coding
  ENST00000560855 EIF2AK4-003 39953975-40035591 protein_coding
  ENST00000624709 EIF2AK4-011 39976979-39978292 TEC

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000263791ENST00000558557ENST00000558823ENST00000559624ENST00000560855
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000263791 5.496±0.00 2.349±0.00 1.760±0.00 2.991±0.30 3.142±0.42 3.486±0.87 3.182±1.26 2.469±0.06 2.912±0.25 2.791±0.50 2.549±0.00 6.368±2.82 7.085±2.72 3.091±0.49
ENST00000558557 N/A N/A N/A N/A N/A N/A N/A 1.615±0.00 N/A N/A N/A N/A N/A N/A
ENST00000558823 N/A 9.271±0.00 N/A N/A N/A N/A N/A 5.317±0.00 N/A N/A N/A N/A N/A N/A
ENST00000559624 N/A N/A N/A N/A 1.625±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000560855 3.466±0.00 4.005±0.00 N/A 2.096±0.00 5.315±0.00 1.536±0.00 N/A 2.622±0.00 1.671±0.00 0.707±0.00 0.389±0.00 1.100±0.00 2.094±0.12 2.920±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008W0 CIL_0008W0_0001 VISTA 15:39791359-40393937
CIL_0006QT CIL_0006QT_0001 CGP 15:39799023-40035591
CIL_0006QZ CIL_0006QZ_0001 CGP 15:39934146-40039188

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004672 IEA protein kinase activity
GO:0004674 ISS:IEA protein serine/threonine kinase activity
GO:0004694 ISS eukaryotic translation initiation factor 2alpha kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IEA protein binding
GO:0005524 IEA ATP binding
GO:0006446 ISS:IEA regulation of translational initiation
GO:0006468 ISS:IEA protein phosphorylation
GO:0009267 IEA cellular response to starvation
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0017148 IEA negative regulation of translation
GO:0022626 ISS cytosolic ribosome
GO:0030968 IEA endoplasmic reticulum unfolded protein response
GO:0042803 IEA protein homodimerization activity
GO:0043558 IEA regulation of translational initiation in response to stress

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000077010 eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 protein_coding Danio_rerio
ENSMUSG00000005102 Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 protein_coding Mus_musculus

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