C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: eukaryotic translation initiation factor 2 alpha kinase 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000005102 Eif2ak4 10090 + 2:118388618-118475234 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000005233 Eif2ak4-001 118388618-118475234 protein_coding
  ENSMUST00000102527 Eif2ak4-201 118389112-118475231 protein_coding
  ENSMUST00000110869 Eif2ak4-006 118438842-118452290 protein_coding
  ENSMUST00000110870 Eif2ak4-004 118412346-118475234 protein_coding
  ENSMUST00000110872 Eif2ak4-003 118389112-118475232 protein_coding
  ENSMUST00000110874 Eif2ak4-002 118388847-118475234 protein_coding
  ENSMUST00000110877 Eif2ak4-005 118388618-118428213 protein_coding
  ENSMUST00000125281 Eif2ak4-007 118457160-118462094 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000005233ENSMUST00000102527ENSMUST00000110870ENSMUST00000110872ENSMUST00000110874ENSMUST00000125281
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000005233 3.519±0.68 5.479±1.51 2.918±0.05 3.498±0.71 2.355±0.56 4.329±0.86 0.871±0.45 2.850±0.86 3.455±1.90 3.658±1.73 0.624±0.21 6.704±3.35 3.919±0.78 1.131±0.36
ENSMUST00000102527 1.085±0.00 N/A N/A 1.806±0.00 1.236±0.00 N/A 0.223±0.00 N/A 0.547±0.08 N/A 0.304±0.08 2.349±0.06 1.651±0.37 0.131±0.00
ENSMUST00000110870 N/A N/A N/A 1.334±0.10 N/A 0.800±0.00 0.278±0.00 N/A N/A N/A N/A N/A N/A 0.329±0.09
ENSMUST00000110872 1.030±0.00 N/A N/A 0.996±0.00 1.054±0.00 N/A 0.218±0.00 N/A 0.535±0.08 N/A 0.294±0.07 2.307±0.06 1.611±0.36 0.120±0.00
ENSMUST00000110874 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.143±0.00 N/A N/A N/A
ENSMUST00000125281 N/A N/A N/A 15.669±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 11.450±4.72 3.279±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008W0 CIL_0008W0_0002 VISTA 2:118232227-118834856
CIL_0006QT CIL_0006QT_0002 CGP 2:118277110-118475234
CIL_0006QZ CIL_0006QZ_0002 CGP 2:118388618-118479711

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004672 IEA protein kinase activity
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004694 IDA eukaryotic translation initiation factor 2alpha kinase activity
GO:0005524 IEA ATP binding
GO:0006446 ISS regulation of translational initiation
GO:0006468 IEA protein phosphorylation
GO:0009267 IDA cellular response to starvation
GO:0017148 IGI negative regulation of translation
GO:0022626 ISS cytosolic ribosome
GO:0030968 IMP endoplasmic reticulum unfolded protein response
GO:0042803 IEA protein homodimerization activity
GO:0043558 IDA regulation of translational initiation in response to stress

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000077010 eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 protein_coding Danio_rerio
ENSG00000128829 EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 protein_coding Homo_sapiens

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