C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: secretion regulating guanine nucleotide exchange factor
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000129158 SERGEF 9606 - 11:17788048-18013162 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000265965 SERGEF-001 17788048-18013162 protein_coding
  ENST00000524589 SERGEF-020 17788052-17863697 processed_transcript
  ENST00000524716 SERGEF-006 18000524-18013012 nonsense_mediated_decay
  ENST00000525168 SERGEF-023 17877847-17959623 processed_transcript
  ENST00000525422 SERGEF-002 17788048-18013036 nonsense_mediated_decay
  ENST00000525920 SERGEF-014 17788249-18004497 protein_coding
  ENST00000527494 SERGEF-011 17788048-18012898 nonsense_mediated_decay
  ENST00000528200 SERGEF-003 17788049-18013028 protein_coding
  ENST00000528369 SERGEF-017 17788048-17939632 processed_transcript
  ENST00000529151 SERGEF-015 17788155-18000804 protein_coding
  ENST00000529440 SERGEF-019 17788052-17995835 processed_transcript
  ENST00000529728 SERGEF-004 17959453-18012929 protein_coding
  ENST00000530613 SERGEF-012 17988605-18012898 protein_coding
  ENST00000530925 SERGEF-008 17992950-18012924 nonsense_mediated_decay
  ENST00000530951 SERGEF-013 18007941-18010342 processed_transcript
  ENST00000531299 SERGEF-022 17788048-17866864 processed_transcript
  ENST00000531926 SERGEF-021 17788048-17874278 processed_transcript
  ENST00000532212 SERGEF-007 17999546-18012928 processed_transcript
  ENST00000532265 SERGEF-005 17846562-18012953 protein_coding
  ENST00000532389 SERGEF-009 17988687-18012924 protein_coding
  ENST00000532546 SERGEF-018 17788196-17995865 nonsense_mediated_decay
  ENST00000533241 SERGEF-016 17846588-17988757 protein_coding
  ENST00000533328 SERGEF-010 17992988-18012918 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000265965ENST00000525168ENST00000525422ENST00000525920ENST00000527494ENST00000528200ENST00000529151ENST00000529440ENST00000530613ENST00000531926ENST00000532389ENST00000533241
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000265965 5.600±0.00 5.605±0.00 5.489±0.00 5.173±0.00 7.567±0.00 1.782±1.42 4.434±0.00 2.090±0.60 4.836±0.00 2.720±0.00 6.449±3.06 1.805±0.36 4.771±0.00
ENST00000525168 N/A N/A N/A N/A N/A 2.605±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000525422 N/A N/A N/A N/A N/A N/A 0.341±0.00 N/A N/A N/A N/A N/A N/A
ENST00000525920 N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.179±0.00 6.552±0.00 7.969±0.00 11.503±0.00
ENST00000527494 N/A N/A 5.182±0.16 N/A N/A N/A 2.244±0.00 N/A N/A N/A N/A N/A N/A
ENST00000528200 3.408±0.00 N/A 8.538±0.00 3.625±0.00 9.201±0.00 1.714±0.00 2.438±1.77 0.913±0.00 3.310±0.00 3.791±0.00 5.111±2.38 0.985±0.19 3.682±0.00
ENST00000529151 N/A N/A 6.481±0.36 N/A N/A N/A 4.571±0.00 4.534±0.00 N/A N/A 10.106±0.00 1.290±0.00 N/A
ENST00000529440 8.697±0.00 12.606±0.00 N/A 10.103±0.00 N/A N/A N/A N/A 6.199±0.00 N/A 29.566±0.00 N/A 15.837±0.00
ENST00000530613 N/A N/A 7.817±0.00 N/A N/A N/A 0.486±0.00 N/A N/A N/A N/A 2.702±0.00 N/A
ENST00000531926 N/A N/A N/A N/A N/A N/A N/A N/A N/A 3.528±0.00 N/A 2.727±0.00 N/A
ENST00000532389 N/A N/A N/A N/A N/A N/A N/A N/A 2.701±0.00 1.955±0.00 3.343±0.00 N/A N/A
ENST00000533241 N/A N/A N/A N/A N/A N/A N/A 4.185±0.00 6.547±0.00 N/A 3.800±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000418 CIL_000418_0002 CGP 11:17734812-18013162
CIL_0001IE CIL_0001IE_0002 CGP 11:17788048-18042426

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005087 TAS Ran guanyl-nucleotide exchange factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005730 IDA nucleolus
GO:0005737 IDA cytoplasm
GO:0007165 TAS signal transduction
GO:0032853 TAS positive regulation of Ran GTPase activity
GO:0045111 IDA intermediate filament cytoskeleton
GO:0050709 IEA:IDA negative regulation of protein secretion

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000070986 sergef secretion regulating guanine nucleotide exchange factor protein_coding Danio_rerio
ENSMUSG00000030839 Sergef secretion regulating guanine nucleotide exchange factor protein_coding Mus_musculus

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