C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: secretion regulating guanine nucleotide exchange factor
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000030839 Sergef 10090 - 7:46443168-46639807 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000033127 Sergef-001 46443168-46639807 protein_coding
  ENSMUST00000124962 Sergef-005 46443474-46614788 processed_transcript
  ENSMUST00000125825 Sergef-004 46632660-46635947 retained_intron
  ENSMUST00000135035 Sergef-002 46632682-46639631 protein_coding
  ENSMUST00000137988 Sergef-003 46632696-46639580 processed_transcript
  ENSMUST00000156147 Sergef-006 46443221-46603242 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000033127ENSMUST00000124962ENSMUST00000125825ENSMUST00000156147
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000033127 3.264±1.37 7.316±1.23 2.926±0.47 10.163±2.76 3.104±1.06 4.342±0.86 1.680±0.29 6.626±0.70 2.812±0.56 4.393±0.32 1.209±0.18 4.887±1.40 2.417±0.94 N/A
ENSMUST00000124962 3.015±0.00 N/A N/A N/A 5.827±0.00 3.847±0.00 1.419±0.00 N/A 3.705±2.21 N/A N/A N/A 0.820±0.00 N/A
ENSMUST00000125825 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.315±0.00 N/A N/A N/A
ENSMUST00000156147 N/A 4.294±0.40 N/A 9.277±0.00 2.612±1.29 1.858±0.70 0.840±0.00 3.500±0.83 1.486±0.60 N/A 0.541±0.00 3.699±1.01 N/A 4.516±0.74

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000418 CIL_000418_0003 CGP 7:46396497-46639807
CIL_0001IE CIL_0001IE_0003 CGP 7:46443168-46672537

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005087 ISA Ran guanyl-nucleotide exchange factor activity
GO:0005515 IEA protein binding
GO:0005634 ISS nucleus
GO:0005730 IEA nucleolus
GO:0005737 ISS cytoplasm
GO:0032853 ISA positive regulation of Ran GTPase activity
GO:0045111 IEA intermediate filament cytoskeleton
GO:0050709 IEA negative regulation of protein secretion

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000070986 sergef secretion regulating guanine nucleotide exchange factor protein_coding Danio_rerio
ENSG00000129158 SERGEF secretion regulating guanine nucleotide exchange factor protein_coding Homo_sapiens

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