C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cyclin-dependent kinase inhibitor 1C (p57, Kip2)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000129757 CDKN1C 9606 - 11:2883213-2885881 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000380725 CDKN1C-002 2883213-2885749 protein_coding
  ENST00000414822 CDKN1C-001 2883213-2885881 protein_coding
  ENST00000430149 CDKN1C-006 2883579-2885771 protein_coding
  ENST00000440480 CDKN1C-003 2883218-2885813 protein_coding
  ENST00000471157 CDKN1C-004 2883675-2884701 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000380725ENST00000414822ENST00000430149ENST00000440480ENST00000471157
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000380725 N/A 1.712±0.00 N/A 6.526±0.00 N/A 13.174±0.00 N/A N/A 0.930±0.00 N/A 4.166±3.60 21.907±6.76 343.272±8.53 3.266±2.82
ENST00000414822 16.551±0.00 1.227±0.00 1.228±0.00 16.756±0.00 11.688±0.00 1.525±0.00 5.123±0.00 N/A N/A 0.759±0.00 3.370±0.00 11.797±0.00 N/A 4.576±0.00
ENST00000430149 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 13.375±0.00 326.755±0.00 N/A
ENST00000440480 51.502±0.00 3.334±0.00 1.474±0.00 11.454±6.42 13.734±11.44 7.980±7.06 11.161±9.22 52.020±51.45 3.938±1.39 12.040±7.90 9.337±6.91 21.510±9.55 398.176±93.69 4.128±2.93
ENST00000471157 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.037±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008A3 CIL_0008A3_0001 VISTA 11:2289701-2893486
CIL_0003FM CIL_0003FM_0002 CGP 11:2444684-2885881

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0001501 IEA skeletal system development
GO:0001822 IEA kidney development
GO:0001890 IEA placenta development
GO:0004861 IEA cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0005737 IDA cytoplasm
GO:0007050 IEA cell cycle arrest
GO:0007568 IEA aging
GO:0030099 IEA myeloid cell differentiation
GO:0030325 IEA adrenal gland development
GO:0030511 IMP positive regulation of transforming growth factor beta receptor signaling pathway
GO:0033673 IDA negative regulation of kinase activity
GO:0035264 IEA multicellular organism growth
GO:0042326 IDA negative regulation of phosphorylation
GO:0042551 IEA neuron maturation
GO:0043010 IEA camera-type eye development
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IGI positive regulation of transcription, DNA-templated
GO:0050680 IMP negative regulation of epithelial cell proliferation
GO:0055123 IEA digestive system development
GO:0060065 IEA uterus development
GO:0060669 IEA embryonic placenta morphogenesis
GO:0071514 IEA genetic imprinting
GO:0071901 IEA negative regulation of protein serine/threonine kinase activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000010878 cdkn1c cyclin-dependent kinase inhibitor 1C protein_coding Danio_rerio
ENSDARG00000089854 CDKN1C (2 of 2) cyclin-dependent kinase inhibitor 1C (p57, Kip2) protein_coding Danio_rerio
ENSMUSG00000037664 Cdkn1c cyclin-dependent kinase inhibitor 1C (P57) protein_coding Mus_musculus

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