C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: SHC (Src homology 2 domain containing) transforming protein 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000129946 SHC2 9606 - 19:416583-460996 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000264554 SHC2-001 416583-460996 protein_coding
  ENST00000587423 SHC2-004 416589-419879 retained_intron
  ENST00000588376 SHC2-003 416589-422828 retained_intron
  ENST00000589922 SHC2-002 422243-441384 retained_intron
  ENST00000590113 SHC2-006 435771-439030 processed_transcript
  ENST00000590170 SHC2-008 417200-436258 nonsense_mediated_decay
  ENST00000590222 SHC2-007 430741-460571 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000264554ENST00000587423ENST00000588376ENST00000589922ENST00000590170ENST00000590222
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000264554 8.087±0.00 7.354±0.00 N/A 6.660±5.50 4.674±4.03 11.314±0.00 4.123±3.78 3.347±2.19 11.212±10.46 1.385±1.25 0.356±0.00 11.853±13.13 13.433±7.31 6.617±1.48
ENST00000587423 N/A 1.490±0.00 0.214±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000588376 N/A 3.126±0.00 N/A 2.249±1.31 N/A 3.032±0.00 N/A 2.343±1.03 0.345±0.00 3.301±2.56 0.261±0.00 3.210±2.82 N/A 2.823±0.00
ENST00000589922 N/A N/A 0.037±0.00 N/A N/A 0.062±0.00 N/A N/A N/A N/A N/A 2.831±0.00 N/A N/A
ENST00000590170 N/A N/A 0.097±0.00 N/A N/A N/A N/A N/A N/A N/A 1.391±0.00 N/A N/A N/A
ENST00000590222 N/A N/A N/A 1.232±0.00 N/A N/A 0.158±0.00 1.507±0.00 N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005CP CIL_0005CP_0001 CGP 19:405438-460996
CIL_0007I4 CIL_0007I4_0001 CGP 19:416583-474983

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000187 IEA activation of MAPK activity
GO:0005515 IPI:IEA protein binding
GO:0005575 ND cellular_component
GO:0005829 TAS cytosol
GO:0007265 TAS Ras protein signal transduction
GO:0008286 TAS insulin receptor signaling pathway
GO:0030971 IEA receptor tyrosine kinase binding
GO:0048011 TAS neurotrophin TRK receptor signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000062080 shc2 SHC (Src homology 2 domain containing) transforming protein 2 protein_coding Danio_rerio
ENSMUSG00000020312 Shc2 SHC (Src homology 2 domain containing) transforming protein 2 protein_coding Mus_musculus

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