C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: GTP cyclohydrolase 1
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000491895 GCH1-002 ENSG00000131979 9606 - 14:54842016-54902852 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalLungPlacentaENST00000491895
Transcript ID Adrenal Lung Placenta
ENST00000491895 1.232±0.00 7.780±0.00 0.779±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000009 CIL_000009_0002 CGP 14:54567097-54902852
CIL_000005 CIL_000005_0002 CGP 14:54842008-55027105

Gene Ontology

GO IDEvidence TypeGO Description
GO:0003934 IDA:IEA GTP cyclohydrolase I activity
GO:0005509 IEA calcium ion binding
GO:0005515 IPI protein binding
GO:0005525 IDA GTP binding
GO:0005634 IDA nucleus
GO:0005737 IDA:IEA cytoplasm
GO:0005829 IDA cytosol
GO:0006184 IDA GTP catabolic process
GO:0006461 IEA protein complex assembly
GO:0006729 IMP tetrahydrobiopterin biosynthetic process
GO:0006809 NAS nitric oxide biosynthetic process
GO:0008152 IDA metabolic process
GO:0008217 IMP regulation of blood pressure
GO:0008270 IDA zinc ion binding
GO:0014916 IEA regulation of lung blood pressure
GO:0030742 IEA GTP-dependent protein binding
GO:0031410 IDA cytoplasmic vesicle
GO:0031965 IDA nuclear membrane
GO:0032496 IDA response to lipopolysaccharide
GO:0034341 IDA response to interferon-gamma
GO:0034612 IDA response to tumor necrosis factor
GO:0035998 IEA 7,8-dihydroneopterin 3'-triphosphate biosynthetic process
GO:0042311 IEA vasodilation
GO:0042416 IDA dopamine biosynthetic process
GO:0042559 IDA pteridine-containing compound biosynthetic process
GO:0042803 IPI protein homodimerization activity
GO:0043234 IDA protein complex
GO:0044281 TAS small molecule metabolic process
GO:0045776 IEA negative regulation of blood pressure
GO:0046209 TAS nitric oxide metabolic process
GO:0046654 IEA tetrahydrofolate biosynthetic process
GO:0048265 ISS response to pain
GO:0050662 IEA coenzyme binding
GO:0050884 IMP neuromuscular process controlling posture
GO:0050999 TAS regulation of nitric-oxide synthase activity
GO:0051000 IDA positive regulation of nitric-oxide synthase activity
GO:0051066 IEA dihydrobiopterin metabolic process
GO:0051260 IDA protein homooligomerization
GO:0051291 IEA protein heterooligomerization

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000089959 Gch1-201 protein_coding Mus_musculus 0 922

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