C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: peroxisome proliferator-activated receptor gamma
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000132170 PPARG 9606 + 3:12287368-12434356 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000287820 PPARG-002 12351472-12434356 protein_coding
  ENST00000309576 PPARG-007 12287860-12434344 protein_coding
  ENST00000396999 PPARG-014 12379706-12417154 nonsense_mediated_decay
  ENST00000397000 PPARG-009 12312388-12434216 protein_coding
  ENST00000397010 PPARG-003 12287368-12434344 protein_coding
  ENST00000397012 PPARG-001 12288838-12434344 protein_coding
  ENST00000397015 PPARG-013 12287901-12434311 protein_coding
  ENST00000397023 PPARG-011 12351569-12434344 nonsense_mediated_decay
  ENST00000397026 PPARG-005 12289071-12434339 protein_coding
  ENST00000397029 PPARG-015 12287388-12381491 protein_coding
  ENST00000438682 PPARG-017 12305773-12381392 protein_coding
  ENST00000455517 PPARG-004 12288838-12379834 protein_coding
  ENST00000477039 PPARG-012 12351472-12406846 retained_intron
  ENST00000497594 PPARG-008 12289111-12406846 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000287820ENST00000309576ENST00000397000ENST00000397010ENST00000397012ENST00000397015ENST00000397023ENST00000497594
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000287820 N/A N/A N/A N/A 8.216±0.00 N/A N/A N/A N/A 3.536±1.77 N/A N/A N/A N/A
ENST00000309576 26.414±0.00 6.968±0.00 N/A N/A 18.479±0.00 7.252±0.00 2.362±0.00 3.967±0.00 1.156±0.00 N/A N/A 4.939±0.00 5.707±0.89 3.971±0.00
ENST00000397000 N/A N/A N/A N/A N/A N/A 2.388±0.00 3.086±0.00 N/A N/A N/A N/A N/A 1.047±0.00
ENST00000397010 N/A N/A 1.211±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000397012 N/A N/A N/A N/A N/A 3.488±0.00 N/A N/A N/A 1.700±0.00 N/A 2.186±0.00 4.335±0.09 N/A
ENST00000397015 24.714±0.00 4.264±0.00 3.373±0.00 1.176±0.29 22.943±13.01 4.973±0.00 4.490±0.00 4.772±0.00 5.565±4.30 6.400±0.00 0.966±0.29 6.108±4.60 20.593±2.17 1.955±0.37
ENST00000397023 N/A N/A N/A N/A N/A N/A 0.572±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000497594 N/A N/A N/A 0.218±0.00 N/A 4.210±0.00 N/A N/A N/A 1.747±0.37 N/A 1.774±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001ZK CIL_0001ZK_0001 CGP 3:12153051-12434356
CIL_0004K9 CIL_0004K9_0001 CGP 3:12287368-12539623

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 ISS negative regulation of transcription from RNA polymerase II promoter
GO:0001012 IEA RNA polymerase II regulatory region DNA binding
GO:0001228 IEA RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001890 ISS placenta development
GO:0002674 IEA negative regulation of acute inflammatory response
GO:0003677 ISS DNA binding
GO:0003682 ISS chromatin binding
GO:0003700 ISS:IEA sequence-specific DNA binding transcription factor activity
GO:0003707 IEA steroid hormone receptor activity
GO:0004879 IEA:IDA ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0004955 TAS prostaglandin receptor activity
GO:0005515 IPI protein binding
GO:0005634 IDA:IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005829 ISS cytosol
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0006367 TAS transcription initiation from RNA polymerase II promoter
GO:0006629 TAS lipid metabolic process
GO:0006919 IDA activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165 IDA signal transduction
GO:0007186 TAS G-protein coupled receptor signaling pathway
GO:0007507 IEA heart development
GO:0007584 TAS response to nutrient
GO:0008134 IEA transcription factor binding
GO:0008144 IDA drug binding
GO:0008217 IMP regulation of blood pressure
GO:0008270 IEA zinc ion binding
GO:0008285 IEA negative regulation of cell proliferation
GO:0009409 IEA response to cold
GO:0009612 IEA response to mechanical stimulus
GO:0010033 IEA response to organic substance
GO:0010467 TAS gene expression
GO:0010745 IC negative regulation of macrophage derived foam cell differentiation
GO:0010871 IDA negative regulation of receptor biosynthetic process
GO:0010887 IDA negative regulation of cholesterol storage
GO:0010891 IDA negative regulation of sequestering of triglyceride
GO:0014070 IEA response to organic cyclic compound
GO:0015909 ISS long-chain fatty acid transport
GO:0019216 IEA regulation of lipid metabolic process
GO:0019395 IEA fatty acid oxidation
GO:0019899 IPI enzyme binding
GO:0019903 IEA protein phosphatase binding
GO:0030224 IDA monocyte differentiation
GO:0030308 IEA negative regulation of cell growth
GO:0030331 IEA estrogen receptor binding
GO:0030374 IDA ligand-dependent nuclear receptor transcription coactivator activity
GO:0030522 IEA intracellular receptor signaling pathway
GO:0030855 ISS epithelial cell differentiation
GO:0031000 IEA response to caffeine
GO:0031100 IEA organ regeneration
GO:0032526 IDA response to retinoic acid
GO:0032869 IMP cellular response to insulin stimulus
GO:0032966 IEA negative regulation of collagen biosynthetic process
GO:0033189 IEA response to vitamin A
GO:0033613 IDA activating transcription factor binding
GO:0033993 ISS response to lipid
GO:0035357 IMP peroxisome proliferator activated receptor signaling pathway
GO:0035902 IEA response to immobilization stress
GO:0036270 IEA response to diuretic
GO:0042493 IEA response to drug
GO:0042593 IMP glucose homeostasis
GO:0042594 IEA response to starvation
GO:0042953 IDA lipoprotein transport
GO:0043065 IEA positive regulation of apoptotic process
GO:0043401 IEA steroid hormone mediated signaling pathway
GO:0043565 IEA:IDA sequence-specific DNA binding
GO:0043627 IEA response to estrogen
GO:0044212 ISS transcription regulatory region DNA binding
GO:0045087 TAS innate immune response
GO:0045165 ISS cell fate commitment
GO:0045444 IEA fat cell differentiation
GO:0045598 IEA regulation of fat cell differentiation
GO:0045600 ISS positive regulation of fat cell differentiation
GO:0045713 IDA low-density lipoprotein particle receptor biosynthetic process
GO:0045892 ISS negative regulation of transcription, DNA-templated
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046321 IEA positive regulation of fatty acid oxidation
GO:0046965 IDA retinoid X receptor binding
GO:0048469 IDA cell maturation
GO:0048471 IEA perinuclear region of cytoplasm
GO:0048662 IDA negative regulation of smooth muscle cell proliferation
GO:0048714 IEA positive regulation of oligodendrocyte differentiation
GO:0050544 ISS arachidonic acid binding
GO:0050872 ISS white fat cell differentiation
GO:0050873 IEA brown fat cell differentiation
GO:0051091 IDA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051974 IEA negative regulation of telomerase activity
GO:0055088 TAS lipid homeostasis
GO:0055098 IDA response to low-density lipoprotein particle
GO:0060100 IEA positive regulation of phagocytosis, engulfment
GO:0060336 IMP negative regulation of interferon-gamma-mediated signaling pathway
GO:0060694 IC regulation of cholesterol transporter activity
GO:0060850 ISS regulation of transcription involved in cell fate commitment
GO:0071285 IEA cellular response to lithium ion
GO:0071300 IEA cellular response to retinoic acid
GO:0071306 IEA cellular response to vitamin E
GO:0071379 IEA cellular response to prostaglandin stimulus
GO:0071380 IEA cellular response to prostaglandin E stimulus
GO:0071407 IEA cellular response to organic cyclic compound
GO:0071455 IEA cellular response to hyperoxia
GO:1901558 IEA response to metformin
GO:2000230 IEA negative regulation of pancreatic stellate cell proliferation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000031848 pparg peroxisome proliferator activated receptor gamma protein_coding Danio_rerio
ENSMUSG00000000440 Pparg peroxisome proliferator activated receptor gamma protein_coding Mus_musculus

Loading