C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000134086 VHL 9606 + 3:10141008-10152220 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000256474 VHL-001 10141008-10152220 protein_coding
  ENST00000345392 VHL-002 10141788-10152082 protein_coding
  ENST00000477538 VHL-003 10142546-10150145 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000256474ENST00000345392ENST00000477538
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000256474 N/A N/A N/A 0.944±0.00 1.429±0.00 1.375±0.00 N/A 0.926±0.00 1.395±0.00 0.502±0.00 N/A 1.916±1.36 0.827±0.00 N/A
ENST00000345392 8.450±0.00 12.538±0.00 1.866±0.00 3.534±0.79 3.984±1.57 1.876±0.52 1.458±0.87 4.874±0.00 2.020±1.04 3.367±1.21 1.193±0.92 3.540±1.18 4.161±2.07 7.019±0.82
ENST00000477538 N/A N/A 1.703±0.00 2.463±0.00 3.065±0.00 N/A N/A N/A 1.471±0.00 3.557±0.28 0.517±0.00 2.026±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00061Q CIL_00061Q_0001 CGP 3:10115592-10152220
CIL_00061P CIL_00061P_0001 CGP 3:10141008-10243743

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 TAS negative regulation of transcription from RNA polymerase II promoter
GO:0000902 NAS cell morphogenesis
GO:0004842 TAS ubiquitin-protein transferase activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005739 NAS mitochondrion
GO:0005783 NAS endoplasmic reticulum
GO:0005829 TAS cytosol
GO:0006355 IMP regulation of transcription, DNA-templated
GO:0006508 TAS proteolysis
GO:0008134 IPI transcription factor binding
GO:0008285 TAS negative regulation of cell proliferation
GO:0016020 IEA membrane
GO:0016567 IEA protein ubiquitination
GO:0019899 IPI enzyme binding
GO:0043066 NAS negative regulation of apoptotic process
GO:0045111 IDA intermediate filament cytoskeleton
GO:0045597 NAS positive regulation of cell differentiation
GO:0045893 IMP positive regulation of transcription, DNA-templated
GO:0050821 NAS protein stabilization
GO:0061418 TAS regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0061428 IDA negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0061630 IDA ubiquitin protein ligase activity
GO:0071456 TAS cellular response to hypoxia

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000070617 vhl von Hippel-Lindau tumor suppressor protein_coding Danio_rerio
ENSMUSG00000033933 Vhl von Hippel-Lindau tumor suppressor protein_coding Mus_musculus

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