C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: von Hippel-Lindau tumor suppressor
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000033933 Vhl 10090 + 6:113623959-113631633 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000035673 Vhl-001 113623959-113631633 protein_coding
  ENSMUST00000128770 Vhl-002 113624721-113629761 processed_transcript
  ENSMUST00000131819 Vhl-003 113624929-113629557 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000035673ENSMUST00000128770ENSMUST00000131819
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000035673 11.659±0.66 18.281±2.14 7.002±0.27 12.049±6.44 10.254±4.38 7.780±1.05 2.865±0.42 7.723±0.31 4.250±0.45 9.642±0.29 1.747±0.72 12.803±5.32 11.673±6.45 15.192±9.25
ENSMUST00000128770 N/A N/A N/A 10.044±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A 44.073±7.43
ENSMUST00000131819 N/A N/A N/A N/A 16.354±0.00 N/A N/A N/A 4.918±0.34 N/A N/A 14.578±0.00 21.530±0.00 61.247±1.70

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00061Q CIL_00061Q_0002 CGP 6:113604772-113631633
CIL_00061P CIL_00061P_0002 CGP 6:113623959-113695009

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0001525 IMP angiogenesis
GO:0001666 IEA response to hypoxia
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 IDA nucleoplasm
GO:0005730 IDA nucleolus
GO:0005737 IDA cytoplasm
GO:0005739 IEA mitochondrion
GO:0005829 IEA cytosol
GO:0005929 IDA cilium
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006607 IMP NLS-bearing protein import into nucleus
GO:0010498 IMP proteasomal protein catabolic process
GO:0015031 IDA protein transport
GO:0016020 IEA membrane
GO:0016567 IEA protein ubiquitination
GO:0030163 IMP protein catabolic process
GO:0030182 IEA neuron differentiation
GO:0030198 IMP extracellular matrix organization
GO:0030891 IEA VCB complex
GO:0031462 IDA Cul2-RING ubiquitin ligase complex
GO:0032403 IDA protein complex binding
GO:0042069 IEA regulation of catecholamine metabolic process
GO:0043534 IMP blood vessel endothelial cell migration
GO:0045471 IEA response to ethanol
GO:0051291 IEA protein heterooligomerization
GO:0070243 IGI regulation of thymocyte apoptotic process
GO:0070244 IMP negative regulation of thymocyte apoptotic process
GO:2001233 IGI regulation of apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000070617 vhl von Hippel-Lindau tumor suppressor protein_coding Danio_rerio
ENSG00000134086 VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase protein_coding Homo_sapiens
ENSG00000189030 VHLL von Hippel-Lindau tumor suppressor-like protein_coding Homo_sapiens

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