C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: purinergic receptor P2X, ligand-gated ion channel, 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000135124 P2RX4 9606 + 12:121209857-121234106 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000314442 P2RX4-013 121212866-121223043 retained_intron
  ENST00000337233 P2RX4-001 121209857-121234106 protein_coding
  ENST00000359949 P2RX4-002 121210065-121234070 protein_coding
  ENST00000397924 P2RX4-007 121222332-121228811 retained_intron
  ENST00000499638 P2RX4-004 121210129-121234104 retained_intron
  ENST00000538417 P2RX4-014 121210235-121232508 nonsense_mediated_decay
  ENST00000538701 P2RX4-011 121210151-121229042 protein_coding
  ENST00000540930 P2RX4-010 121210129-121228614 processed_transcript
  ENST00000541187 P2RX4-012 121210171-121232507 retained_intron
  ENST00000542067 P2RX4-005 121210165-121233547 protein_coding
  ENST00000543171 P2RX4-201 121209861-121234104 protein_coding
  ENST00000543318 P2RX4-006 121210129-121233737 nonsense_mediated_decay
  ENST00000543430 P2RX4-008 121210117-121233547 retained_intron
  ENST00000543984 P2RX4-009 121210129-121234106 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000314442ENST00000337233ENST00000359949ENST00000499638ENST00000540930ENST00000542067ENST00000543171ENST00000543318ENST00000543430ENST00000543984
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000314442 0.330±0.00 N/A 0.192±0.00 0.224±0.00 0.884±0.00 0.373±0.00 N/A 0.161±0.00 N/A N/A N/A 0.766±0.00 N/A N/A
ENST00000337233 1.902±0.00 5.453±0.00 1.873±0.00 1.549±0.00 3.696±0.00 3.331±0.94 N/A 5.915±0.00 4.421±0.00 7.124±4.56 N/A 9.905±6.05 45.690±2.01 7.137±0.00
ENST00000359949 N/A N/A N/A N/A N/A N/A 1.361±0.00 1.192±0.00 0.345±0.00 N/A N/A 0.891±0.00 N/A N/A
ENST00000499638 N/A 1.246±0.00 N/A 0.527±0.00 N/A N/A N/A N/A N/A 0.546±0.00 N/A N/A N/A N/A
ENST00000540930 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 31.724±0.00 N/A
ENST00000542067 N/A N/A N/A N/A N/A N/A 0.319±0.00 0.748±0.00 N/A N/A N/A N/A N/A N/A
ENST00000543171 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 9.199±0.00 10.470±0.00 N/A
ENST00000543318 3.381±0.00 N/A N/A N/A 1.661±0.00 2.160±0.00 N/A N/A 2.435±0.00 N/A 0.577±0.00 N/A N/A N/A
ENST00000543430 N/A N/A N/A 1.101±0.00 N/A N/A 0.159±0.00 N/A N/A N/A 0.144±0.00 N/A N/A N/A
ENST00000543984 3.298±0.00 4.377±0.00 0.754±0.00 1.811±0.13 3.289±0.37 N/A 0.958±0.78 3.465±2.01 3.105±1.27 0.791±0.00 1.401±0.00 9.513±8.87 23.488±12.51 3.071±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002ZL CIL_0002ZL_0001 CGP 12:121132819-121234106
CIL_0002ZK CIL_0002ZK_0001 CGP 12:121209857-121298308

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001614 IMP:IEA purinergic nucleotide receptor activity
GO:0001894 NAS tissue homeostasis
GO:0002028 ISS regulation of sodium ion transport
GO:0004931 IDA extracellular ATP-gated cation channel activity
GO:0005102 ISS receptor binding
GO:0005216 IEA ion channel activity
GO:0005507 ISS copper ion binding
GO:0005515 IEA protein binding
GO:0005524 IEA:IC ATP binding
GO:0005639 IBA integral component of nuclear inner membrane
GO:0005765 IDA lysosomal membrane
GO:0005886 ISS plasma membrane
GO:0005887 IMP integral component of plasma membrane
GO:0006809 IEA nitric oxide biosynthetic process
GO:0006810 IDA transport
GO:0006811 IEA ion transport
GO:0006816 IEA calcium ion transport
GO:0007165 IDA signal transduction
GO:0008144 IEA drug binding
GO:0008217 IMP regulation of blood pressure
GO:0008270 ISS zinc ion binding
GO:0010524 IMP positive regulation of calcium ion transport into cytosol
GO:0010614 IMP negative regulation of cardiac muscle hypertrophy
GO:0014069 IEA postsynaptic density
GO:0016020 IDA:IEA membrane
GO:0016021 IEA integral component of membrane
GO:0019228 IEA neuronal action potential
GO:0019233 ISS sensory perception of pain
GO:0030054 IDA cell junction
GO:0030424 IEA axon
GO:0030425 IEA dendrite
GO:0032308 NAS positive regulation of prostaglandin secretion
GO:0033198 IDA response to ATP
GO:0034220 IDA ion transmembrane transport
GO:0034405 IDA response to fluid shear stress
GO:0035590 IMP purinergic nucleotide receptor signaling pathway
GO:0042118 TAS endothelial cell activation
GO:0042311 IEA vasodilation
GO:0042803 NAS protein homodimerization activity
GO:0043025 IEA neuronal cell body
GO:0043195 IEA terminal bouton
GO:0043197 IEA dendritic spine
GO:0045177 IEA apical part of cell
GO:0045202 IEA synapse
GO:0045296 IPI cadherin binding
GO:0045429 NAS positive regulation of nitric oxide biosynthetic process
GO:0048471 IDA perinuclear region of cytoplasm
GO:0050850 IMP positive regulation of calcium-mediated signaling
GO:0051260 IEA protein homooligomerization
GO:0051899 IDA membrane depolarization
GO:0051928 NAS positive regulation of calcium ion transport
GO:0055117 IMP regulation of cardiac muscle contraction
GO:0055119 IMP relaxation of cardiac muscle
GO:0060079 IEA regulation of excitatory postsynaptic membrane potential
GO:0070062 IDA extracellular vesicular exosome
GO:0071318 IDA cellular response to ATP
GO:0097190 IDA apoptotic signaling pathway
GO:0098655 IDA cation transmembrane transport

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000042452 p2rx4b purinergic receptor P2X, ligand-gated ion channel, 4b protein_coding Danio_rerio
ENSDARG00000044752 p2rx4a purinergic receptor P2X, ligand-gated ion channel, 4a protein_coding Danio_rerio
ENSMUSG00000029470 P2rx4 purinergic receptor P2X, ligand-gated ion channel 4 protein_coding Mus_musculus

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