C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: purinergic receptor P2X, ligand-gated ion channel, 4
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000359949 P2RX4-002 ENSG00000135124 9606 + 12:121210065-121234070 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; HeartKidneyLiverOvaryENST00000359949
Transcript ID Heart Kidney Liver Ovary
ENST00000359949 1.361±0.00 1.192±0.00 0.345±0.00 0.891±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002ZL CIL_0002ZL_0001 CGP 12:121132819-121234106
CIL_0002ZK CIL_0002ZK_0001 CGP 12:121209857-121298308

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001614 IMP:IEA purinergic nucleotide receptor activity
GO:0001894 NAS tissue homeostasis
GO:0002028 ISS regulation of sodium ion transport
GO:0004931 IDA extracellular ATP-gated cation channel activity
GO:0005102 ISS receptor binding
GO:0005216 IEA ion channel activity
GO:0005507 ISS copper ion binding
GO:0005515 IEA protein binding
GO:0005524 IEA:IC ATP binding
GO:0005639 IBA integral component of nuclear inner membrane
GO:0005765 IDA lysosomal membrane
GO:0005886 ISS plasma membrane
GO:0005887 IMP integral component of plasma membrane
GO:0006809 IEA nitric oxide biosynthetic process
GO:0006810 IDA transport
GO:0006811 IEA ion transport
GO:0006816 IEA calcium ion transport
GO:0007165 IDA signal transduction
GO:0008144 IEA drug binding
GO:0008217 IMP regulation of blood pressure
GO:0008270 ISS zinc ion binding
GO:0010524 IMP positive regulation of calcium ion transport into cytosol
GO:0010614 IMP negative regulation of cardiac muscle hypertrophy
GO:0014069 IEA postsynaptic density
GO:0016020 IDA:IEA membrane
GO:0016021 IEA integral component of membrane
GO:0019228 IEA neuronal action potential
GO:0019233 ISS sensory perception of pain
GO:0030054 IDA cell junction
GO:0030424 IEA axon
GO:0030425 IEA dendrite
GO:0032308 NAS positive regulation of prostaglandin secretion
GO:0033198 IDA response to ATP
GO:0034220 IDA ion transmembrane transport
GO:0034405 IDA response to fluid shear stress
GO:0035590 IMP purinergic nucleotide receptor signaling pathway
GO:0042118 TAS endothelial cell activation
GO:0042311 IEA vasodilation
GO:0042803 NAS protein homodimerization activity
GO:0043025 IEA neuronal cell body
GO:0043195 IEA terminal bouton
GO:0043197 IEA dendritic spine
GO:0045177 IEA apical part of cell
GO:0045202 IEA synapse
GO:0045296 IPI cadherin binding
GO:0045429 NAS positive regulation of nitric oxide biosynthetic process
GO:0048471 IDA perinuclear region of cytoplasm
GO:0050850 IMP positive regulation of calcium-mediated signaling
GO:0051260 IEA protein homooligomerization
GO:0051899 IDA membrane depolarization
GO:0051928 NAS positive regulation of calcium ion transport
GO:0055117 IMP regulation of cardiac muscle contraction
GO:0055119 IMP relaxation of cardiac muscle
GO:0060079 IEA regulation of excitatory postsynaptic membrane potential
GO:0070062 IDA extracellular vesicular exosome
GO:0071318 IDA cellular response to ATP
GO:0097190 IDA apoptotic signaling pathway
GO:0098655 IDA cation transmembrane transport

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000031429 P2rx4-001 protein_coding Mus_musculus 0 1053
ENSMUST00000142664 P2rx4-004 protein_coding Mus_musculus 0 856
ENSMUST00000081554 P2rx4-002 protein_coding Mus_musculus 0 627
ENSMUST00000139631 P2rx4-003 protein_coding Mus_musculus 0 427
ENSMUST00000152337 P2rx4-005 retained_intron Mus_musculus 0 196
ENSMUST00000132062 P2rx4-006 retained_intron Mus_musculus 0 191

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