C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: cyclin-dependent kinase 4
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000257904 CDK4-001 ENSG00000135446 9606 - 12:57747727-57752521 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBladderKidneyLiverLungOvaryPlacentaENST00000257904
Transcript ID Adrenal Bladder Kidney Liver Lung Ovary Placenta
ENST00000257904 15.849±0.00 2.613±0.00 20.164±0.00 2.425±0.00 12.339±5.87 19.327±15.79 26.203±0.23

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002KQ CIL_0002KQ_0002 CGP 12:57723761-57750211

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000082 IMP G1/S transition of mitotic cell cycle
GO:0000278 TAS mitotic cell cycle
GO:0000307 IDA cyclin-dependent protein kinase holoenzyme complex
GO:0000785 IDA chromatin
GO:0002088 IEA lens development in camera-type eye
GO:0004672 IEA protein kinase activity
GO:0004693 IDA cyclin-dependent protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005667 IEA transcription factor complex
GO:0005730 IDA nucleolus
GO:0005829 IDA cytosol
GO:0005923 IEA tight junction
GO:0006468 IDA:IEA protein phosphorylation
GO:0007165 IEA signal transduction
GO:0007623 IEA circadian rhythm
GO:0008284 IMP positive regulation of cell proliferation
GO:0009636 IEA response to toxic substance
GO:0010033 IEA response to organic substance
GO:0010288 IEA response to lead ion
GO:0010468 IMP regulation of gene expression
GO:0010971 IDA positive regulation of G2/M transition of mitotic cell cycle
GO:0016301 IEA kinase activity
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0030332 IPI cyclin binding
GO:0031100 IEA organ regeneration
GO:0031965 IDA nuclear membrane
GO:0032403 IEA protein complex binding
GO:0033574 IEA response to testosterone
GO:0042127 IEA regulation of cell proliferation
GO:0042493 IGI response to drug
GO:0043065 IEA positive regulation of apoptotic process
GO:0045727 IEA positive regulation of translation
GO:0045793 IEA positive regulation of cell size
GO:0048146 IMP positive regulation of fibroblast proliferation
GO:0048471 IEA perinuclear region of cytoplasm
GO:0051301 IEA cell division
GO:0051726 IEA regulation of cell cycle
GO:0055093 IEA response to hyperoxia
GO:0071157 IDA negative regulation of cell cycle arrest

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000006911 Cdk4-001 protein_coding Mus_musculus 0 1321
ENSMUST00000133115 Cdk4-006 protein_coding Mus_musculus 0 1038
ENSMUST00000125682 Cdk4-005 protein_coding Mus_musculus 0 1002
ENSMUST00000140254 Cdk4-003 retained_intron Mus_musculus 0 885
ENSMUST00000120079 Gm7158-001 processed_pseudogene Mus_musculus 0 767
ENSMUST00000142558 Cdk4-009 nonsense_mediated_decay Mus_musculus 0 671
ENSMUST00000120226 Cdk4-004 protein_coding Mus_musculus 0 473
ENSMUST00000123456 Cdk4-007 retained_intron Mus_musculus 0 196
ENSMUST00000118922 Gm13521-001 processed_pseudogene Mus_musculus 2e-28 132

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