C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: sodium channel, voltage-gated, type VII, alpha subunit
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000136546 SCN7A 9606 - 2:166403573-166494247 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000409855 SCN7A-001 166403573-166486968 protein_coding
  ENST00000419992 SCN7A-002 166432321-166494247 protein_coding
  ENST00000424326 SCN7A-003 166405513-166486968 nonsense_mediated_decay
  ENST00000441411 SCN7A-004 166456953-166494205 protein_coding
  ENST00000497562 SCN7A-005 166461755-166465526 retained_intron
  ENST00000619410 SCN7A-201 166403573-166486971 protein_coding
  ENST00000621965 SCN7A-202 166403573-166486971 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000409855ENST00000419992ENST00000424326ENST00000441411ENST00000619410ENST00000621965
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000409855 0.589±0.00 0.095±0.00 N/A 0.070±0.00 0.177±0.00 5.706±0.00 3.362±0.76 1.267±0.00 0.316±0.00 3.337±0.66 N/A 3.847±0.00 0.568±0.40 0.464±0.20
ENST00000419992 N/A N/A 0.124±0.00 N/A 1.437±0.00 N/A N/A 0.290±0.00 2.766±0.00 7.762±0.00 0.271±0.00 N/A N/A N/A
ENST00000424326 N/A N/A N/A 0.047±0.00 0.460±0.00 N/A N/A N/A N/A N/A 0.167±0.00 N/A N/A N/A
ENST00000441411 N/A N/A N/A N/A N/A N/A 5.915±0.00 0.712±0.00 N/A N/A 1.168±0.00 5.398±0.00 N/A N/A
ENST00000619410 N/A N/A N/A 0.070±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 0.258±0.00 0.260±0.00
ENST00000621965 N/A N/A N/A 0.070±0.00 N/A N/A N/A N/A N/A N/A N/A N/A 0.152±0.00 0.243±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006CV CIL_0006CV_0001 CGP 2:166195185-166494247

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001518 IEA voltage-gated sodium channel complex
GO:0005216 IEA ion channel activity
GO:0005248 IEA:IBA voltage-gated sodium channel activity
GO:0005272 IEA sodium channel activity
GO:0005515 IEA protein binding
GO:0005886 IBA plasma membrane
GO:0006811 IEA ion transport
GO:0006814 TAS:IEA sodium ion transport
GO:0006936 IEA muscle contraction
GO:0016020 IEA membrane
GO:0019228 IBA neuronal action potential
GO:0034765 IEA regulation of ion transmembrane transport
GO:0035725 IEA:IBA sodium ion transmembrane transport
GO:0055078 IEA sodium ion homeostasis
GO:0055085 IEA transmembrane transport
GO:0086010 IBA membrane depolarization during action potential
GO:0097386 IEA glial cell projection

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000010783 scn1a sodium channel, voltage-gated, type I, alpha protein_coding Danio_rerio
ENSDARG00000062744 scn1lab sodium channel, voltage-gated, type I like, alpha b protein_coding Danio_rerio
ENSMUSG00000034810 Scn7a sodium channel, voltage-gated, type VII, alpha protein_coding Mus_musculus

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