C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000136750 GAD2 9606 + 10:26216307-26304558 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000259271 GAD2-002 26216665-26304558 protein_coding
  ENST00000376248 GAD2-004 26218193-26224760 protein_coding
  ENST00000376261 GAD2-001 26216307-26304558 protein_coding
  ENST00000428517 GAD2-003 26216733-26219320 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBrainBreastLiverPlacentaTestisENST00000259271ENST00000376261
Transcript ID Adipose Brain Breast Liver Placenta Testis
ENST00000259271 N/A 3.629±0.00 0.004±0.00 N/A N/A 0.193±0.10
ENST00000376261 0.008±0.00 5.712±0.01 0.013±0.00 0.008±0.00 0.013±0.00 0.155±0.07

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001XV CIL_0001XV_0001 CGP 10:25934267-26304558
CIL_0000R5 CIL_0000R5_0001 CGP 10:26216307-26567803

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004351 IEA glutamate decarboxylase activity
GO:0005515 IPI protein binding
GO:0005794 IEA Golgi apparatus
GO:0005829 IEA cytosol
GO:0005886 TAS plasma membrane
GO:0006540 IEA glutamate decarboxylation to succinate
GO:0007268 TAS synaptic transmission
GO:0007269 TAS neurotransmitter secretion
GO:0016595 IEA glutamate binding
GO:0016831 IEA carboxy-lyase activity
GO:0019752 IEA carboxylic acid metabolic process
GO:0030054 IEA cell junction
GO:0030170 IEA pyridoxal phosphate binding
GO:0030424 IEA axon
GO:0030672 IEA synaptic vesicle membrane
GO:0031225 IEA anchored component of membrane
GO:0031410 IEA cytoplasmic vesicle
GO:0042136 IEA neurotransmitter biosynthetic process
GO:0042493 IEA response to drug
GO:0045202 IEA synapse
GO:0046982 IEA protein heterodimerization activity
GO:0048471 IEA perinuclear region of cytoplasm
GO:0061202 TAS clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000015537 gad2 glutamate decarboxylase 2 protein_coding Danio_rerio
ENSMUSG00000026787 Gad2 glutamic acid decarboxylase 2 protein_coding Mus_musculus

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