C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: BRCA1 associated RING domain 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000138376 BARD1 9606 - 2:214725646-214809711 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000260947 BARD1-001 214725646-214809704 protein_coding
  ENST00000421162 BARD1-005 214730411-214809687 protein_coding
  ENST00000432456 BARD1-004 214728538-214730508 protein_coding
  ENST00000449967 BARD1-201 214728553-214809642 protein_coding
  ENST00000455743 BARD1-003 214728704-214809673 nonsense_mediated_decay
  ENST00000465841 BARD1-006 214745712-214752478 retained_intron
  ENST00000471590 BARD1-002 214728424-214731145 processed_transcript
  ENST00000471787 BARD1-007 214780897-214809670 processed_transcript
  ENST00000479904 BARD1-008 214796794-214809660 retained_intron
  ENST00000613192 BARD1-202 214728676-214809683 protein_coding
  ENST00000613374 BARD1-203 214725646-214809711 protein_coding
  ENST00000613706 BARD1-204 214725646-214809711 protein_coding
  ENST00000617164 BARD1-205 214725646-214809711 protein_coding
  ENST00000619009 BARD1-206 214725646-214809711 protein_coding
  ENST00000620057 BARD1-207 214728677-214809642 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000260947ENST00000449967ENST00000455743ENST00000471787ENST00000613192ENST00000613374ENST00000617164ENST00000619009ENST00000620057
Transcript ID Adipose Adrenal Bladder Brain Breast Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000260947 N/A N/A 0.391±0.00 0.452±0.24 N/A 0.215±0.00 N/A N/A N/A 0.525±0.13 0.893±0.40 0.424±0.11 1.537±0.29
ENST00000449967 N/A N/A N/A N/A N/A 0.225±0.00 0.302±0.00 N/A N/A 0.321±0.00 1.054±0.00 N/A N/A
ENST00000455743 0.243±0.00 N/A N/A 0.321±0.00 N/A N/A N/A 0.631±0.48 N/A N/A N/A N/A N/A
ENST00000471787 N/A N/A N/A N/A N/A 0.920±0.00 N/A N/A N/A 1.259±0.00 N/A N/A N/A
ENST00000613192 N/A N/A N/A N/A N/A N/A 0.429±0.00 N/A N/A N/A N/A N/A N/A
ENST00000613374 N/A N/A N/A N/A 0.287±0.00 N/A N/A N/A N/A 0.240±0.00 0.296±0.00 0.081±0.00 N/A
ENST00000617164 0.317±0.00 0.353±0.00 N/A 0.580±0.00 N/A 0.216±0.00 0.090±0.00 N/A 0.364±0.00 0.298±0.00 N/A 0.505±0.00 1.489±0.00
ENST00000619009 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.410±0.00 0.458±0.00 1.128±0.00
ENST00000620057 N/A N/A N/A 1.033±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000AI CIL_0000AI_0002 CGP 2:214411065-214809711
CIL_0000AP CIL_0000AP_0002 CGP 2:214725646-215138428

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000151 NAS ubiquitin ligase complex
GO:0001894 TAS tissue homeostasis
GO:0003723 IDA RNA binding
GO:0004842 NAS ubiquitin-protein transferase activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005730 IDA nucleolus
GO:0005737 IDA cytoplasm
GO:0006281 IEA DNA repair
GO:0006974 NAS cellular response to DNA damage stimulus
GO:0007050 NAS cell cycle arrest
GO:0008270 IEA zinc ion binding
GO:0016567 NAS protein ubiquitination
GO:0016874 IEA ligase activity
GO:0019900 NAS kinase binding
GO:0031436 IDA BRCA1-BARD1 complex
GO:0031441 NAS negative regulation of mRNA 3'-end processing
GO:0042325 IMP regulation of phosphorylation
GO:0042803 IPI protein homodimerization activity
GO:0043065 IMP positive regulation of apoptotic process
GO:0043066 IMP negative regulation of apoptotic process
GO:0043231 IDA intracellular membrane-bounded organelle
GO:0045732 NAS positive regulation of protein catabolic process
GO:0046826 IDA negative regulation of protein export from nucleus
GO:0046982 IPI protein heterodimerization activity
GO:0070531 IDA BRCA1-A complex
GO:0085020 IDA protein K6-linked ubiquitination

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000076733 bard1 BRCA1 associated RING domain 1 protein_coding Danio_rerio
ENSMUSG00000026196 Bard1 BRCA1 associated RING domain 1 protein_coding Mus_musculus

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