C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000138411 HECW2 9606 - 2:196194370-196593692 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000260983 HECW2-001 196194370-196592611 protein_coding
  ENST00000409111 HECW2-002 196199251-196362222 protein_coding
  ENST00000427457 HECW2-004 196343703-196593554 protein_coding
  ENST00000452031 HECW2-003 196343657-196593692 protein_coding
  ENST00000462290 HECW2-006 196257736-196278679 retained_intron
  ENST00000498146 HECW2-005 196240460-196242255 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000260983ENST00000409111
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000260983 N/A 0.174±0.00 N/A 2.418±0.00 0.146±0.00 0.112±0.00 1.606±0.46 N/A 0.359±0.00 0.533±0.00 N/A 0.066±0.00 0.488±0.20 0.299±0.12
ENST00000409111 0.906±0.00 0.833±0.00 0.739±0.00 0.800±0.00 0.505±0.22 0.132±0.03 2.061±0.37 1.030±0.00 0.402±0.18 5.909±0.00 0.061±0.04 0.527±0.25 1.950±0.40 1.327±0.27

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002KD CIL_0002KD_0001 CGP 2:196133566-196593692
CIL_0002KC CIL_0002KC_0001 CGP 2:196194370-196763490

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004842 IBA:IEA ubiquitin-protein transferase activity
GO:0005515 IEA protein binding
GO:0005634 IBA nucleus
GO:0005737 IBA cytoplasm
GO:0016874 IEA ligase activity
GO:0042787 IBA protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000062447 hecw2a HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2a protein_coding Danio_rerio
ENSDARG00000063253 HECW2 (2 of 2) HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 protein_coding Danio_rerio
ENSMUSG00000042807 Hecw2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 protein_coding Mus_musculus

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