C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: isocitrate dehydrogenase 1 (NADP+), soluble
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000138413 IDH1 9606 - 2:208236227-208266074 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000345146 IDH1-001 208236227-208255133 protein_coding
  ENST00000415282 IDH1-009 208245367-208254339 protein_coding
  ENST00000415913 IDH1-006 208236265-208254322 protein_coding
  ENST00000417583 IDH1-008 208248562-208255798 protein_coding
  ENST00000446179 IDH1-004 208236232-208254458 protein_coding
  ENST00000451391 IDH1-007 208248597-208266074 protein_coding
  ENST00000462386 IDH1-003 208247382-208255061 retained_intron
  ENST00000481557 IDH1-010 208251261-208255113 retained_intron
  ENST00000484575 IDH1-012 208236742-208240315 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000345146ENST00000415913ENST00000446179ENST00000451391ENST00000462386ENST00000481557
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000345146 36.593±0.00 13.359±0.00 7.408±0.00 4.474±0.03 42.338±35.47 14.784±2.58 4.435±0.63 40.200±17.71 34.310±24.45 7.867±0.14 0.939±0.28 35.880±14.01 39.693±3.76 23.489±2.30
ENST00000415913 N/A N/A N/A N/A N/A N/A 0.522±0.00 N/A N/A N/A 0.315±0.00 N/A N/A N/A
ENST00000446179 N/A N/A 4.981±0.00 0.900±0.06 N/A 2.148±0.00 3.705±0.00 N/A 22.872±0.00 N/A 1.993±0.00 9.547±0.00 N/A 7.140±0.00
ENST00000451391 N/A N/A N/A N/A N/A 25.912±0.00 N/A 62.142±0.00 27.890±0.00 N/A 4.683±0.00 39.929±0.86 73.231±0.00 N/A
ENST00000462386 N/A N/A N/A N/A N/A N/A 0.799±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000481557 N/A N/A 12.293±0.00 3.700±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00045J CIL_00045J_0001 CGP 2:208165343-208266074
CIL_00014C CIL_00014C_0001 CGP 2:208236227-208358751

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000287 IDA magnesium ion binding
GO:0004450 IDA:IEA isocitrate dehydrogenase (NADP+) activity
GO:0005102 IPI receptor binding
GO:0005737 IDA cytoplasm
GO:0005739 IEA mitochondrion
GO:0005777 IDA peroxisome
GO:0005782 TAS peroxisomal matrix
GO:0005829 IDA cytosol
GO:0006097 IEA glyoxylate cycle
GO:0006099 IEA tricarboxylic acid cycle
GO:0006102 IEA:IDA isocitrate metabolic process
GO:0006103 IDA 2-oxoglutarate metabolic process
GO:0006740 TAS NADPH regeneration
GO:0006749 IEA glutathione metabolic process
GO:0006979 IEA response to oxidative stress
GO:0008585 IEA female gonad development
GO:0014070 IEA response to organic cyclic compound
GO:0016616 IEA oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042803 IPI protein homodimerization activity
GO:0044255 TAS cellular lipid metabolic process
GO:0044281 TAS small molecule metabolic process
GO:0048545 IEA response to steroid hormone
GO:0050661 IEA NADP binding
GO:0051287 IEA NAD binding
GO:0055114 IEA oxidation-reduction process
GO:0070062 IDA extracellular vesicular exosome

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000025375 idh1 isocitrate dehydrogenase 1 (NADP+), soluble protein_coding Danio_rerio
ENSMUSG00000025950 Idh1 isocitrate dehydrogenase 1 (NADP+), soluble protein_coding Mus_musculus

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