C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: fibroblast growth factor 2 (basic)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000138685 FGF2 9606 + 4:122826708-122898236 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000264498 FGF2-001 122826708-122898236 protein_coding
  ENST00000608478 FGF2-002 122826831-122895464 protein_coding
  ENST00000614010 FGF2-201 122826708-122898235 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000264498ENST00000608478ENST00000614010
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000264498 2.696±0.00 0.844±0.00 0.595±0.00 1.801±0.37 2.849±1.07 1.743±0.77 0.394±0.15 0.649±0.29 1.224±1.10 1.551±0.51 0.174±0.10 0.791±0.52 0.576±0.08 0.613±0.00
ENST00000608478 N/A N/A N/A N/A N/A N/A 0.348±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000614010 2.763±0.00 1.739±0.00 0.600±0.00 3.249±1.80 3.728±1.94 2.400±1.43 0.411±0.15 0.655±0.29 1.268±1.14 3.395±2.35 0.178±0.10 1.099±0.89 0.584±0.08 1.414±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006YN CIL_0006YN_0002 CGP 4:122826708-122922968

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000186 IEA activation of MAPKK activity
GO:0000187 TAS activation of MAPK activity
GO:0001525 IEA angiogenesis
GO:0001658 IDA branching involved in ureteric bud morphogenesis
GO:0001759 IEA organ induction
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0001938 IEA positive regulation of endothelial cell proliferation
GO:0002042 IDA cell migration involved in sprouting angiogenesis
GO:0005104 IEA fibroblast growth factor receptor binding
GO:0005125 IDA cytokine activity
GO:0005515 IEA protein binding
GO:0005576 TAS extracellular region
GO:0005615 IEA extracellular space
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0005829 IEA cytosol
GO:0006661 IDA phosphatidylinositol biosynthetic process
GO:0006935 TAS chemotaxis
GO:0007165 NAS signal transduction
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007265 TAS Ras protein signal transduction
GO:0007399 TAS nervous system development
GO:0007568 IEA aging
GO:0008083 IEA growth factor activity
GO:0008201 IEA heparin binding
GO:0008284 IEA positive regulation of cell proliferation
GO:0008285 IEA negative regulation of cell proliferation
GO:0008286 TAS insulin receptor signaling pathway
GO:0008543 IEA fibroblast growth factor receptor signaling pathway
GO:0009792 IEA embryo development ending in birth or egg hatching
GO:0009887 TAS organ morphogenesis
GO:0010001 IEA glial cell differentiation
GO:0010595 IEA positive regulation of endothelial cell migration
GO:0010628 IEA positive regulation of gene expression
GO:0010764 IDA negative regulation of fibroblast migration
GO:0010863 IDA positive regulation of phospholipase C activity
GO:0021762 IEA substantia nigra development
GO:0021940 IEA positive regulation of cerebellar granule cell precursor proliferation
GO:0030198 TAS extracellular matrix organization
GO:0030214 IDA hyaluronan catabolic process
GO:0030324 IEA lung development
GO:0030374 IDA ligand-dependent nuclear receptor transcription coactivator activity
GO:0032958 IDA inositol phosphate biosynthetic process
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0042056 IDA chemoattractant activity
GO:0042060 IEA wound healing
GO:0042660 IDA positive regulation of cell fate specification
GO:0043536 IDA positive regulation of blood vessel endothelial cell migration
GO:0043537 IDA negative regulation of blood vessel endothelial cell migration
GO:0043552 IDA positive regulation of phosphatidylinositol 3-kinase activity
GO:0045087 TAS innate immune response
GO:0045597 IEA positive regulation of cell differentiation
GO:0045669 IEA positive regulation of osteoblast differentiation
GO:0045765 TAS regulation of angiogenesis
GO:0045766 IEA positive regulation of angiogenesis
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0046668 IEA regulation of retinal cell programmed cell death
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0048598 TAS embryonic morphogenesis
GO:0048661 IEA positive regulation of smooth muscle cell proliferation
GO:0048678 IEA response to axon injury
GO:0048864 IEA stem cell development
GO:0050679 IEA positive regulation of epithelial cell proliferation
GO:0050918 IDA positive chemotaxis
GO:0051209 IDA release of sequestered calcium ion into cytosol
GO:0051726 IEA regulation of cell cycle
GO:0051781 IEA positive regulation of cell division
GO:0051897 IEA positive regulation of protein kinase B signaling
GO:0060045 IEA positive regulation of cardiac muscle cell proliferation
GO:0060128 IEA corticotropin hormone secreting cell differentiation
GO:0060129 IEA thyroid-stimulating hormone-secreting cell differentiation
GO:0060548 IDA negative regulation of cell death
GO:0060591 IDA chondroblast differentiation
GO:0060644 IEA mammary gland epithelial cell differentiation
GO:0060978 IEA angiogenesis involved in coronary vascular morphogenesis
GO:0061045 IDA negative regulation of wound healing
GO:0070374 IEA positive regulation of ERK1 and ERK2 cascade
GO:0090263 IEA positive regulation of canonical Wnt signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000075031 fgf2 fibroblast growth factor 2 protein_coding Danio_rerio
ENSMUSG00000037225 Fgf2 fibroblast growth factor 2 protein_coding Mus_musculus

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