C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: milk fat globule-EGF factor 8 protein
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000140545 MFGE8 9606 - 15:88898683-88913411 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000268150 MFGE8-001 88898714-88913411 protein_coding
  ENST00000268151 MFGE8-004 88898713-88913381 protein_coding
  ENST00000542878 MFGE8-003 88899315-88913379 protein_coding
  ENST00000557944 MFGE8-013 88910780-88913362 retained_intron
  ENST00000558018 MFGE8-005 88898683-88913379 nonsense_mediated_decay
  ENST00000558029 MFGE8-007 88901551-88913362 protein_coding
  ENST00000558352 MFGE8-002 88906063-88913379 retained_intron
  ENST00000558773 MFGE8-012 88910204-88913317 retained_intron
  ENST00000559143 MFGE8-011 88909792-88910257 retained_intron
  ENST00000559259 MFGE8-010 88905382-88906716 retained_intron
  ENST00000559770 MFGE8-009 88906615-88910125 retained_intron
  ENST00000559997 MFGE8-014 88905399-88913379 processed_transcript
  ENST00000560553 MFGE8-008 88903790-88904928 processed_transcript
  ENST00000560937 MFGE8-006 88899298-88901960 retained_intron
  ENST00000566497 MFGE8-015 88898715-88913381 protein_coding
  ENST00000613965 MFGE8-017 88902183-88906661 nonsense_mediated_decay
  ENST00000617199 MFGE8-016 88902183-88904646 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000268150ENST00000268151ENST00000542878ENST00000558018ENST00000558029ENST00000559770ENST00000560937ENST00000566497ENST00000613965ENST00000617199
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000268150 55.510±0.00 53.326±0.00 1.475±0.00 4.650±3.28 12.762±9.48 78.761±77.06 30.315±25.16 10.031±0.00 2.462±0.67 34.144±32.42 32.559±27.22 67.051±36.25 75.513±26.48 75.277±57.89
ENST00000268151 N/A 43.532±0.00 N/A N/A 15.400±12.63 1.012±0.00 N/A N/A N/A 0.641±0.00 N/A 33.183±0.00 N/A N/A
ENST00000542878 61.896±0.00 67.479±0.00 N/A 11.549±0.00 46.871±0.00 1.390±0.00 48.300±0.00 15.374±0.00 2.818±0.00 N/A 54.553±0.00 22.877±20.48 50.218±0.00 18.393±0.00
ENST00000558018 N/A N/A N/A 0.928±0.00 N/A N/A 2.276±0.00 N/A N/A N/A N/A 43.170±0.00 N/A N/A
ENST00000558029 N/A N/A N/A N/A N/A N/A N/A N/A 2.690±0.00 N/A N/A N/A N/A N/A
ENST00000559770 N/A N/A 1.585±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000560937 N/A N/A N/A N/A N/A N/A N/A N/A 3.952±0.00 N/A N/A N/A N/A N/A
ENST00000566497 44.096±0.00 N/A N/A 9.439±0.00 54.384±0.00 90.313±0.00 60.215±0.00 25.463±0.00 2.492±1.12 80.868±0.00 58.715±0.00 N/A 38.429±4.76 N/A
ENST00000613965 N/A N/A N/A N/A N/A N/A N/A N/A N/A 2.442±0.00 N/A N/A N/A N/A
ENST00000617199 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.844±0.00 2.658±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00011I CIL_00011I_0001 CGP 15:88877288-88913411
CIL_00011J CIL_00011J_0001 CGP 15:88898683-89202360

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001525 IEA angiogenesis
GO:0001786 IEA phosphatidylserine binding
GO:0005178 IEA integrin binding
GO:0005515 IEA protein binding
GO:0005576 TAS extracellular region
GO:0005615 IDA extracellular space
GO:0006910 IEA phagocytosis, recognition
GO:0006911 IEA phagocytosis, engulfment
GO:0007155 IEA cell adhesion
GO:0007338 IEA single fertilization
GO:0008429 IEA phosphatidylethanolamine binding
GO:0009897 IEA external side of plasma membrane
GO:0016020 IDA membrane
GO:0016032 IEA viral process
GO:0019897 IEA extrinsic component of plasma membrane
GO:0031012 IDA extracellular matrix
GO:0031982 IDA vesicle
GO:0050766 IEA positive regulation of phagocytosis
GO:0070062 IDA extracellular vesicular exosome
GO:2000427 IEA positive regulation of apoptotic cell clearance

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000015349 mfge8a milk fat globule-EGF factor 8 protein a protein_coding Danio_rerio
ENSDARG00000045803 mfge8b milk fat globule-EGF factor 8 protein b protein_coding Danio_rerio
ENSMUSG00000030605 Mfge8 milk fat globule-EGF factor 8 protein protein_coding Mus_musculus

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